Arrested replication forks guide retrotransposon integration
| Autor: | Susanne Cranz-Mileva, Jesus D. Rosado-Lugo, Vincent Tournier, Jake Z. Jacobs, Mikel Zaratiegui, Keith M. Ciccaglione |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
DNA Replication
Genetics Host genome Multidisciplinary Retroelements biology Terminal Repeat Sequences DNA replication food and beverages Retrotransposon biology.organism_classification DNA-binding protein Article Replication (computing) Long terminal repeat DNA-Binding Proteins Mutagenesis Insertional Target site Schizosaccharomyces Schizosaccharomyces pombe Proteins |
| Zdroj: | Science. 349:1549-1553 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aaa3810 |
| Popis: | Parasitic DNA targets a genomic home Long-terminal-repeat (LTR) retrotransposons are a form of parasitic DNA that can jump around within the host's genome. To avoid damaging resident genes, they have been selected to integrate away from protein-coding sequences. For instance, the fission yeast LTR retrotransposon Tf1 inserts at nucleosome-free regions in gene promoters. Jacobs et al. show that Tf1 is directed to these insertion sites by a specific DNA binding protein, Sap1, which forms DNA replication–fork barriers. Science , this issue p. 1549 |
| Databáze: | OpenAIRE |
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