Relationship between prenatal or postnatal exposure to pesticides and obesity: a systematic review
| Autor: | Cristian Pérez-Fernández, Ana Merchán, Maria Teresa Colomina, Fernando Sánchez-Santed, Beatriz Carrillo, Jorge L. Arias, Helena Pinos, Paloma Collado, Judit Biosca-Brull, Nélida M. Conejo, Fernando Martin-Sanchez |
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| Přispěvatelé: | European Regional Development Fund, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III |
| Rok vydání: | 2021 |
| Předmět: |
Adult
obesity Offspring Health Toxicology and Mutagenesis organophosphate carbamates Review 010501 environmental sciences Overweight 01 natural sciences chlorpyrifos 03 medical and health sciences chemistry.chemical_compound Neonicotinoids pyrethroids Pregnancy Environmental health Pyrethrins Medicine Humans Child 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Hormone activity business.industry Organophosphate Public Health Environmental and Occupational Health Environmental Exposure pesticides Pesticide medicine.disease Obesity Organophosphates chemistry Chlorpyrifos organochlorine Female Animal studies neonicotinoids medicine.symptom business |
| Zdroj: | Scopus RUO. Repositorio Institucional de la Universidad de Oviedo instname riUAL. Repositorio Institucional de la Universidad de Almería Universidad de Almería International Journal of Environmental Research and Public Health Repisalud Instituto de Salud Carlos III (ISCIII) International Journal of Environmental Research and Public Health, Vol 18, Iss 7170, p 7170 (2021) |
| Popis: | In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. These compounds could act as endocrine-disrupting chemicals (EDC) that may interfere with hormone activity related to several mechanisms involved in body weight control. The main objective of this study was to systematically review the data provided in the scientific literature for a possible association between prenatal and postnatal exposure to pesticides and obesity in offspring. A total of 25 human and 9 animal studies were analyzed. The prenatal, perinatal, and postnatal exposure to organophosphate, organochlorine, pyrethroid, neonicotinoid, and carbamate, as well as a combined pesticide exposure was reviewed. This systematic review reveals that the effects of pesticide exposure on body weight are mostly inconclusive, finding conflicting results in both humans and experimental animals. The outcomes reviewed are dependent on many factors, including dosage and route of administration, species, sex, and treatment duration. More research is needed to effectively evaluate the impact of the combined effects of different pesticides on human health. This study was supported by grants from the Spanish Government (Ministerio de Economía y Competitividad and Instituto Mixto de Investigación-Escuela Nacional de Sanidad (IMIENS)) and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER) Grant numbers: PSI2017-90806-REDT, PSI2017-83038-P, PSI2017-83893-R, PSI2017-86396-P, PSI2017-86847-C2-2-R MINECO-FEDER, and IMIENS: PIC-IMIENS-2018-003. Sí |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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