Bond stability of conventional adhesive system with MMP inhibitors to superficial and deep dentin
| Autor: | Cristiane Mariote Amaral, Maria Elisa da Silva Nunes Gomes Miranda, Rafaela da Silva Gonçalves Bezerra, Fabiana Souza Simmer, Eduardo Moreira da Silva, Jaime Dutra Noronha Filho |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
MMP Inhibitors Adolescent Surface Properties Phenylalanine Biomedical Engineering 02 engineering and technology Thiophenes In Vitro Techniques Matrix Metalloproteinase Inhibitors Composite Resins Biomaterials 03 medical and health sciences Young Adult 0302 clinical medicine Acid Etching Dental Adhesives Tensile Strength Adhesive system Materials Testing Dentin medicine Single bond Humans Chlorhexidine diacetate Chemistry Bond strength Chlorhexidine Dental Bonding Tryptophan 030206 dentistry 021001 nanoscience & nanotechnology Resin Cements medicine.anatomical_structure Solubility Mechanics of Materials Dentin-Bonding Agents Linear Models Adper single bond 2 Stress Mechanical 0210 nano-technology Batimastat Nuclear chemistry |
| Zdroj: | Journal of the mechanical behavior of biomedical materials. 100 |
| ISSN: | 1878-0180 |
| Popis: | Purpose To evaluate the microshear bond strength (μSBS) to deep (DD) or superficial (SD) dentin (μSBS) overtime, nanoleakage (AG%), degree of conversion (DC%), water sorption (WSp), and solubility (WSl) of an adhesive system [Adper Single Bond 2(ASB)] containing matrix metalloproteinases (MMP) inhibitors [GM1489 (ASB-GM), Batimastat (ASB-BAT), or Chlorhexidine diacetate (ASB-CHX)]. ASB without inhibitor was used as control (CONTROL). Materials and methods WSp and WSL were calculated based on ISO4049. DC% was analyzed using FT-IR spectroscopy. Dentin discs were used for μSBS evaluation. For AG%, resin-dentin beams were analyzed under scanning electronic microscopy. Data were analyzed using three-way ANOVA (AG% and μSBS) or ANOVA (DC%, WSp, WSl) and Tukey’s HSD test. Results ASB-CHX presented the lowest DC%, lowest WSp, and highest WSl. ASB-GM reached the highest immediate μSBS in SD, only different from ASB-CHX. In DD, ASB-BAT and ASB-GM had the highest μSBS, statistically different from ASB-CHX. After twelve months, ASB-GM and ASB-BAT presented higher μSBS in SD when compared to CONTROL and ASB-CHX. In DD, ASB-GM reached the highest value, which was statistically different from CONTROL and ASB-CHX. CONTROL at both dentin depths and ASB-CHX at DD did not maintain bond stability. In SD after 12 months, ASB-BAT and ASB-GM decreased AG%. In DD, only ASB-GM reduced AG%. Conclusion The ASB containing Batimastat and GM1489 maintained resin-dentin bond stability after 12 months for both dentin depths, without jeopardizing WSp, WSl, or DC% of the adhesive system. The ASB-GM presented greater μSBS after 12 months when compared with ASB. Clinical significance Batimastat and GM1489 could be suitable for inclusion as an MMP-inhibitor into Single Bond to improve the bond stability to superficial and deep dentin, without jeopardize the physic-mechanical proprieties. |
| Databáze: | OpenAIRE |
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