Relationship of adiponectin and its multimers to metabolic indices in cats during weight change
| Autor: | Susan D. Lauten, Joseph W. Bartges, Angela Witzel, Claudia A. Kirk, Stephen A. Kania, H. Byrd, Raymond C. Boston, Tammy Moyers |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Adipokine Adipose tissue Biology chemistry.chemical_compound Endocrinology Food Animals Internal medicine Weight Loss medicine Animals CATS Adiponectin Cholesterol Insulin Leptin Weight change nutritional and metabolic diseases food and beverages Overweight chemistry Body Composition Cats Animal Science and Zoology Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Domestic animal endocrinology. 53 |
| ISSN: | 1879-0054 |
| Popis: | Adiponectin is an important anti-inflammatory hormone secreted from adipose tissue. The high-molecular-weight form of adiponectin (HMW) closely correlates with insulin sensitivity in human beings. This study uses a novel method of size-exclusion gel chromatography combined with enzyme-linked immunosorbent assay to measure HMW feline adiponectin and determine its relationship to leptin, cholesterol, and insulin sensitivity as cats gain and lose weight. In addition, total adiponectin and its messenger RNA expression in subcutaneous adipose tissue were measured. No correlations were found between total serum adiponectin and subcutaneous adipose messenger RNA expression, fat mass, or measures of insulin sensitivity. This study demonstrates that cats have high percentages of HMW adiponectin. Although weak correlations between HMW adiponectin and fat mass were detected, additional cats are needed to determine if the correlations are significant. |
| Databáze: | OpenAIRE |
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