Individual Participant Data Meta-Analysis Provides No Evidence of Intervention Response Variation in Individuals Supplementing With Beta-Alanine
| Autor: | Gabriel Perri Esteves, Ruth M. James, Paul Swinton, Bruno Gualano, Guilherme Giannini Artioli, Craig Sale, Eimear Dolan, Hamilton Roschel, Bryan Saunders |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Time Factors Medicine (miscellaneous) beta-Alanine 030204 cardiovascular system & hematology Placebo Standard deviation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bias Double-Blind Method Intervention (counseling) Internal medicine Medicine Humans Orthopedics and Sports Medicine Muscle Skeletal Randomized Controlled Trials as Topic Change score Nutrition and Dietetics Exercise Tolerance SUPLEMENTOS DIETÉTICOS business.industry Individual participant data Carnosine Bayes Theorem 030229 sport sciences General Medicine Bicycling Sports Nutritional Physiological Phenomena Variation (linguistics) chemistry Meta-analysis Dietary Supplements business |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1543-2742 |
| Popis: | Currently, little is known about the extent of interindividual variability in response to beta-alanine (BA) supplementation, nor what proportion of said variability can be attributed to external factors or to the intervention itself (intervention response). To investigate this, individual participant data on the effect of BA supplementation on a high-intensity cycling capacity test (CCT110%) were meta-analyzed. Changes in time to exhaustion (TTE) and muscle carnosine were the primary and secondary outcomes. Multilevel distributional Bayesian models were used to estimate the mean and SD of BA and placebo group change scores. The relative sizes of group SDs were used to infer whether observed variation in change scores were due to intervention or non-intervention-related effects. Six eligible studies were identified, and individual data were obtained from four of these. Analyses showed a group effect of BA supplementation on TTE (7.7, 95% credible interval [CrI] [1.3, 14.3] s) and muscle carnosine (18.1, 95% CrI [14.5, 21.9] mmol/kg DM). A large intervention response variation was identified for muscle carnosine (σIR = 5.8, 95% CrI [4.2, 7.4] mmol/kg DM) while equivalent change score SDs were shown for TTE in both the placebo (16.1, 95% CrI [13.0, 21.3] s) and BA (15.9, 95% CrI [13.0, 20.0] s) conditions, with the probability that SD was greater in placebo being 0.64. In conclusion, the similarity in observed change score SDs between groups for TTE indicates the source of variation is common to both groups, and therefore unrelated to the supplement itself, likely originating instead from external factors such as nutritional intake, sleep patterns, or training status. |
| Databáze: | OpenAIRE |
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