Nafion-Based Nanocarriers for Fluorine Magnetic Resonance Imaging
| Autor: | Wiktoria Tomal, Marta Szczęch, Krzysztof Jasiński, Władysław P. Węglarz, Natalia Łopuszyńska, Piotr Warszyński, Krzysztof Szczepanowicz |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
medicine.diagnostic_test chemistry.chemical_element Magnetic resonance imaging Nanotechnology 02 engineering and technology Surfaces and Interfaces 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Article 0104 chemical sciences chemistry.chemical_compound chemistry Nafion Drug delivery cardiovascular system Electrochemistry medicine Fluorine General Materials Science Nanocarriers 0210 nano-technology Spectroscopy |
| Zdroj: | Langmuir |
| ISSN: | 1520-5827 0743-7463 |
| Popis: | The aim of our study was to develop a novel method for nanocarriers’ preparation as a fluorine magnetic resonance imaging (19F MRI)-detectable drug delivery system. The novelty of the proposed approach is based on the application of fluorinated polyelectrolyte Nafion as a contrast agent since typical MRI contrast agents are based on paramagnetic gadolinium or ferro/superparamagnetic iron oxide compounds. An advantage of using an 19F-based tracer comes from the fact that the 19F image is detected at a different resonance frequency than the 1H image. In addition, the close to zero natural concentration of 19F nuclei in the human body makes fluorine atoms a promising MRI marker without any natural background signal. That creates the opportunity to localize and identify only exogenous fluorinated compounds with 100% specificity. The nanocarriers were formed by the deposition of polyelectrolytes on nanoemulsion droplets via the layer-by-layer technique with the saturation approach. The polyelectrolyte multilayer shell was composed of Nafion, the fluorinated ionic polymer used for labeling by 19F nuclei, and poly-l-lysine (PLL). The surface of such prepared nanocarriers was further pegylated by adsorption of pegylated polyanion, poly-l-glutamic acid (PGA). The 19F MRI-detectable hydrophobic nanocarriers with an average size of 170 nm and a sufficient signal-to-noise ratio have been developed and optimized to be used for passive tumor targeting and drug delivery. |
| Databáze: | OpenAIRE |
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