Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications

Autor: Teresa Vilariño-García, Sergio Montserrat-de la Paz, María del Carmen Millán-Linares, Carlos Jiménez-Cortegana, Víctor Sánchez-Margalet, Antonio Pérez-Pérez, Francisco J. G. Muriana
Přispěvatelé: Instituto de Salud Carlos III
Rok vydání: 2019
Předmět:
0301 basic medicine
Leptin
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Adipose Tissue
White
Clinical Biochemistry
Leptin resistance
Postprandial metabolism
Adipose tissue
030209 endocrinology & metabolism
Inflammation
White adipose tissue
Biochemistry
Energy homeostasis
Autoimmune Diseases
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal medicine
Neoplasms
medicine
Diabetes Mellitus
Animals
Humans
Nutritional Physiological Phenomena
Obesity
Molecular Biology
Nutrition and Dietetics
business.industry
digestive
oral
and skin physiology
Fatty Acids
medicine.disease
Gestational diabetes
030104 developmental biology
Endocrinology
Adipose Tissue
Infertility
Female
medicine.symptom
business
Energy Intake
Energy Metabolism
hormones
hormone substitutes
and hormone antagonists
Zdroj: The Journal of nutritional biochemistry. 89
ISSN: 1873-4847
Popis: 1 Tabla.-- 1 Figura
In obesity, an elevated accumulation and dysregulation of adipose tissue, due to an imbalance between energy intake and energy expenditure, usually coexists with the loss of responsiveness to leptin in central nervous system, and subsequently with hyperleptinemia. Leptin, a peptide hormone mainly produced by white adipose tissue, regulates energy homeostasis by stimulating energy expenditure and inhibiting food intake. Human obesity is characterized by increased plasma leptin levels, which have been related with different obesity-associated complications, such as chronic inflammatory state (risk factor for diabetes, cardiovascular and autoimmune diseases), as well as infertility and different types of cancer. Besides, leptin is also produced by placenta, and high leptin levels during pregnancy may be related with some pathological conditions such as gestational diabetes. This review focuses on the current insights and emerging concepts on potentially valuable nutrients and food components that may modulate leptin metabolism. Notably, several dietary food components, such as phenols, peptides, and vitamins, are able to decrease inflammation and improve leptin sensitivity by up- or down-regulation of leptin signaling molecules. On the other hand, some food components, such as saturated fatty acids may worsen chronic inflammation increasing the risk for pathological complications. Future research into nutritional mechanisms that restore leptin metabolism and signals of energy homeostasis may inspire new treatment options for obesity-related disorders.
The present work was funded by grants from the Instituto de Salud Carlos III (ISCIII), PS12/00117, and PI15/01535, PI19/01741 funded in part by FEDER Funds, to Víctor Sánchez-Margalet.
Databáze: OpenAIRE
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