Nedocromil sodium in obstructive airways disease: effect on symptoms and plasma protein leakage in sputum
| Autor: | D. F. M. Schoonbrood, Hm Jansen, Theo A. Out, A.A.M. Hart, C.M. Roos, F.J.M. Habets |
|---|---|
| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
Nedocromil Male medicine.medical_specialty medicine.drug_class Anti-Inflammatory Agents Gastroenterology Double-Blind Method Bronchodilator Internal medicine Forced Expiratory Volume medicine Humans Lung Diseases Obstructive Nedocromil Sodium Asthma Inhalation business.industry Albumin Sputum Blood Proteins Middle Aged respiratory system medicine.disease Blood proteins respiratory tract diseases Immunology Female medicine.symptom business medicine.drug |
| Zdroj: | European respiratory journal, 10(7), 1500-1506. European Respiratory Society |
| ISSN: | 0903-1936 |
| DOI: | 10.1183/09031936.97.10071500 |
| Popis: | In patients with asthma or chronic obstructive pulmonary disease, there is chronic airway inflammation with increased leakage of plasma proteins into the airway lumen, which can be reduced by inhaled glucocorticosteroids. Nedocromil sodium is an anti-inflammatory drug, and we questioned whether it also affects the leakage of plasma proteins. In a double-blind placebo-controlled study we investigated the effect of 12 weeks of treatment with nedocromil on forced expiratory volume in one second (FEV1), provocative concentration of histamine causing a 20% fall in FEV1 (PC20), peak flow, symptom scores, and plasma protein leakage in sputum, in 31 patients with obstructive airways disease and sputum production (mean (range) FEV1 61% of predicted (42-87%); geometric mean (range) PC20 0.39 (0.04-2.9) mg x mL(-1)). As a measure for plasma protein leakage we calculated the relative coefficients of excretion (RCE) of proteins from serum to the soluble phase of sputum. There was a small increase in morning and evening peak flow (p |
| Databáze: | OpenAIRE |
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