Neutrophil gelatinase-associated lipocalin and its receptors in Alzheimers disease (AD) brain regions : differential findings in AD with and without depression
| Autor: | Doortje W. Dekens, Petrus J.W. Naudé, Yannick Vermeiren, Sebastiaan Engelborghs, Debby Van Dam, Ulrich L. M. Eisel, Richard C. Oude Voshaar, Peter Paul De Deyn |
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| Přispěvatelé: | Clinical sciences, Neurology, Eisel lab, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Molecular Neuroscience and Ageing Research (MOLAR) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine MILD COGNITIVE IMPAIRMENT hippocampus LATE-LIFE DEPRESSION Hippocampus INFLAMMATORY MARKERS PREFRONTAL CORTEX Lipocalin 24p3R Lipocalin-2/blood 0302 clinical medicine NGAL Prefrontal cortex Depression (differential diagnoses) Medicine(all) AMYLOID BETA-PEPTIDE Depression General Neuroscience Brain General Medicine Alzheimer's disease Late life depression Low Density Lipoprotein Receptor-Related Protein-2 Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Depression/complications depression lipocalin 2 Female medicine.symptom APOLIPOPROTEIN J Psychology Alzheimer’s disease Research Article medicine.medical_specialty Alzheimer Disease/complications Central nervous system Enzyme-Linked Immunosorbent Assay Receptors Cell Surface Inflammation VASCULAR-DEMENTIA 03 medical and health sciences CEREBROSPINAL-FLUID Lipocalin-2 Alzheimer Disease Internal medicine medicine Brain/metabolism Humans Receptors Cell Surface/metabolism Vascular dementia Biology Psychiatric Status Rating Scales Analysis of Variance Low Density Lipoprotein Receptor-Related Protein-2/metabolism Other Research Radboud Institute for Health Sciences [Radboudumc 0] CENTRAL-NERVOUS-SYSTEM MAJOR DEPRESSION medicine.disease 030104 developmental biology Endocrinology inflammation Human medicine Geriatrics and Gerontology megalin 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease Journal of Alzheimer's Disease Journal of alzheimers disease, 55(2), 763-776. IOS Press Journal of Alzheimer's Disease, 55, 2, pp. 763-776 Journal of Alzheimer's Disease, 55, 763-776 Journal of Alzheimer's Disease, 55(2), 763-776 Journal of Alzheimer's Disease 55 (2017) 2 |
| ISSN: | 1387-2877 |
| Popis: | Contains fulltext : 171035.pdf (Publisher’s version ) (Open Access) Co-existing depression worsens Alzheimer's disease (AD) pathology. Neutrophil gelatinase-associated lipocalin (NGAL) is a newly identified (neuro)inflammatory mediator in the pathophysiologies of both AD and depression. This study aimed to compare NGAL levels in healthy controls, AD without depression (AD-D), and AD with co-existing depression (AD+D) patients. Protein levels of NGAL and its receptors, 24p3R and megalin, were assessed in nine brain regions from healthy controls (n = 19), AD-D (n = 19), and AD+D (n = 21) patients. NGAL levels in AD-D patients were significantly increased in brain regions commonly associated with AD. In the hippocampus, NGAL levels were even further increased in AD+D subjects. Unexpectedly, NGAL levels in the prefrontal cortex of AD+D patients were comparable to those in controls. Megalin levels were increased in BA11 and amygdala of AD+D patients, while no changes in 24p3R were detected. These findings indicate significant differences in neuroimmunological regulation between AD patients with and without co-existing depression. Considering its known effects, elevated NGAL levels might actively promote neuropathological processes in AD with and without depression. |
| Databáze: | OpenAIRE |
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