High Prevalence of Polycystic Ovary Syndrome in Type 1 Diabetes Mellitus Adolescents: Is There a Difference Depending on the NIH and Rotterdam Criteria?
| Autor: | Evelyne Jacqz-Aigrain, Christine Delcroix, D. Martin, Maud Bidet, Nadia Tubiana-Rufi, K. Laborde, Ana Colmenares, Dinane Samara-Boustani, Jean-Jacques Robert, Claire Levy-Marchal, L. Benadjaoud, Kanetee Busiah, Paul Jacquin, Michel Polak |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Diabetes Complications Adult women 03 medical and health sciences 0302 clinical medicine Endocrinology Prevalence Humans Medicine Child Gynecology Type 1 diabetes 030219 obstetrics & reproductive medicine High prevalence business.industry Puberty Hyperandrogenism nutritional and metabolic diseases medicine.disease Polycystic ovary Oligomenorrhea Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Pediatrics Perinatology and Child Health Female business Polycystic Ovary Syndrome |
| Zdroj: | Hormone Research in Paediatrics. 87:333-341 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000471805 |
| Popis: | Background: Polycystic ovary syndrome (PCOS) is more frequently observed in type 1 diabetes mellitus (T1DM) adult women than in nondiabetic women. No such prevalence has yet been studied in adolescent girls with T1DM. Aim: The aim of this study was to evaluate the prevalence of PCOS in adolescent girls with T1DM and to determine the clinical and hormonal features associated with the disorder. Methods: A cross-sectional study of 53 adolescent girls (gynecological age >2 years) referred for routine evaluation for T1DM was conducted. We diagnosed PCOS using the National Institutes of Health (NIH) and Rotterdam criteria. Results: 26.4 and 47.9% of adolescents had PCOS according to NIH (NIH-PCOS) and Rotterdam (Rotterdam-PCOS) criteria. 66.7% of NIH-PCOS adolescents had a complete phenotype associated with hyperandrogenism, oligomenorrhea, and polycystic ovarian morphology, unlike only 33.3% of the Rotterdam-PCOS adolescents. A family history of type 2 diabetes mellitus (T2DM) was more frequent in PCOS than in non-PCOS girls, whichever criteria were used. Late pubertal development and a T1DM diagnosis close to puberty were factors associated with NIH-PCOS. Conclusion: Adolescents with T1DM had a high prevalence of PCOS. More differences between PCOS and non-PCOS patients were found using the NIH criteria, suggesting that clinical characteristics might be more accurate for diagnosing PCOS in girls with T1DM. A family history of T2DM is associated with a high risk of PCOS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|