| Autor: |
Jin Kyung Suh, Young Kwon Koh, Sung Han Kang, Hyery Kim, Eun Seok Choi, Kyung-Nam Koh, Ho Joon Im |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Blood research. 57(2) |
| ISSN: |
2287-979X |
| Popis: |
The incorporation of a reduced-intensity conditioning (RIC) regimen in hematopoietic cell transplantation (HCT) for patients with hemophagocytic lymphohistiocytosis (HLH) has decreased early mortality but is associated with a high rate of mixed chimerism and graft failure. Here, we present a successful single-center experience using busulfan and a fludarabine-based RIC regimen for the treatment of HLH.The medical records of pediatric patients with HLH who underwent HCT using a busulfan/ fludarabine-based RIC regimen between January 2008 and December 2017 were reviewed retrospectively.Nine patients received HCT with a busulfan/fludarabine-based RIC regimen. Three patients had primary HLH, and the other six patients had secondary HLH with multiple reactivations. All three patients with primary HLH hadOur experience suggests that a busulfan/fludarabine-based RIC regimen is a viable option for pediatric patients with HLH who require HCT. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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