Dexamethasone treatment induces long-lasting hyperleptinemia and anorexia in old rats
| Autor: | F. Gachon, Luc Cynober, Christophe Moinard, M.-P. Vasson, R. Minet-Quinard, F. Caldefie-Ch zet |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
Leptin Male Aging medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Anorexia Dexamethasone Rats Sprague-Dawley Eating Basal (phylogenetics) Endocrinology Metabolic Diseases Stress Physiological Internal medicine medicine Animals Insulin business.industry Body Weight digestive oral and skin physiology Metabolism Rats Disease Models Animal Corticosteroid medicine.symptom business hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | Metabolism. 50:1054-1058 |
| ISSN: | 0026-0495 |
| DOI: | 10.1053/meta.2001.25803 |
| Popis: | Aging brings poor adaptation to stress, the causes of which remain unclear. We previously reported impairment of nitrogen metabolism in glucocorticoid-treated old rats due to profound anorexia. Here we investigated whether leptin, a satiety hormone, was implicated in impaired adaptation to stress. Plasma glucose and insulin levels, which are known to modulate leptin secretion, were also studied. Adult (3 months, n = 18) and aged (24 months, n = 18) rats were treated with dexamethasone (DEX) (1.5 mg/kg/d, intraperitoneal [IP] injection) for 3, 5, and 7 days. Results were compared with ad libitum (n = 12) and pair-fed groups, receiving intraperitoneal saline injection, for each age (n = 6 per group). Transitory anorexia was observed in adult rats (day 3 to day 5), whereas anorexia persisted in aged rats until day 7. This anorexia was associated (r = -.65, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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