Changes in the serum composition of free-fatty acids during an intravenous glucose tolerance test
| Autor: | Jose L. Gallego-Perales, Francisco J. Tinahones, Jose Manuel García-Almeida, Lourdes Garrido-Sánchez, Isabel Cardona, Federico Soriguer, Jose Rivas-Marín, Juan Garcia-Arnes, Eduardo García-Fuentes, Sara García-Serrano |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Blood sugar Bariatric Surgery Type 2 diabetes Fatty Acids Nonesterified Body Mass Index Endocrinology Internal medicine Weight Loss medicine Humans Insulin Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus Carbohydrate Glucose Tolerance Test Middle Aged medicine.disease Obesity Obesity Morbid lipids (amino acids peptides and proteins) Composition (visual arts) Female Intravenous Glucose Tolerance Test business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Obesity (Silver Spring, Md.). 17(1) |
| ISSN: | 1930-7381 |
| Popis: | Recent studies suggest that measuring the free-fatty acids (FFA) during an intravenous glucose tolerance test (IVGTT) may provide information about the metabolic associations between serum FFA and carbohydrate and insulin metabolism. We evaluated the FFA profile during an IVGTT and determined whether this test changes the composition and concentration of FFA. An IVGTT was given to 38 severely obese persons before and 7 months after undergoing bariatric surgery and also to 12 healthy, nonobese persons. The concentration and composition of the FFA were studied at different times during the test. The concentration of FFA fell significantly faster during the IVGTT in the controls and in the severely obese persons with normal-fasting glucose (NFG) than in the severely obese persons with impaired-fasting glucose (IFG) or type 2 diabetes mellitus (T2DM) (P < 0.05). Significant differences were found in the time to minimum serum concentrations of FFA (control = NFG < IFG < T2DM) (P < 0.001). These variables improved after bariatric surgery in the three groups. The percentage of monounsaturated and n-6 polyunsaturated FFA in the control subjects and in the obese persons, both before and after surgery, decreased significantly during the IVGTT. In conclusion, during an IVGTT, severely obese persons with IFG or T2DM experienced a lower fall in the FFA than the severely obese persons with NFG and the controls, becoming normal after bariatric surgery. |
| Databáze: | OpenAIRE |
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