Prostacyclin as a critical prostanoid in adipogenesis
| Autor: | R. Négrel |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Adipose tissue Prostanoid Prostacyclin Cell Biology Biology Epoprostenol chemistry.chemical_compound Paracrine signalling Endocrinology Adipose Tissue Brown chemistry Adipogenesis Internal medicine Adipocyte Prostaglandins cardiovascular system medicine Animals Humans lipids (amino acids peptides and proteins) Arachidonic acid Autocrine signalling medicine.drug |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 60:383-386 |
| ISSN: | 0952-3278 |
| Popis: | Adipose cell differentiation from adipoblasts to preadipose and to adipose cells is a multistep process. Terminal differentiation of preadipose cells expressing early markers to adipose cells expressing late and very late markers and accumulating triacylglycerol requires a combination of circulating and locally-produced hormones. Prostacyclin (PGI2), one of the major metabolites of arachidonic acid in adipose tissue, has been shown to exert autocrine and paracrine adipogenic effects in vitro. As discussed herein, multiple arguments support the proposition that PGI2 is a key prostanoid involved in adipogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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