Holding T cells in check – a new role for complement regulators?
| Autor: | M. Paula Longhi, Awen Gallimore, Claire L. Harris, B. Paul Morgan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Innate immune system
CD46 T-Lymphocytes T cell Immunology CD59 Antigens chemical and pharmacologic phenomena Complement System Proteins Complement receptor Biology Ligands Lymphocyte Activation Acquired immune system Classical complement pathway medicine.anatomical_structure Antigen medicine Animals Humans Immunology and Allergy Decay-accelerating factor Transcription Factors |
| Zdroj: | Trends in Immunology. 27:102-108 |
| ISSN: | 1471-4906 |
| DOI: | 10.1016/j.it.2005.12.008 |
| Popis: | Complement is not only part of the innate immune system, but has also been implicated in adaptive immunity. The role of complement and its regulatory proteins in modulating T cell activity has been the focus of several recent studies. These, which have included work on the membrane co-factor protein (MCP or CD46), decay accelerating factor (DAF or CD55) and CD59, indicate that complement regulators can influence the proliferative capacity of T cells and their ability to produce cytokines, influencing the outcome of a T cell response to a given antigen. Here we review these studies, which reveal another important link between the innate and the adaptive immune system. |
| Databáze: | OpenAIRE |
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