Obesity II: Establishing causal links between chemical exposures and obesity

Autor: Jerrold J. Heindel, Sarah Howard, Keren Agay-Shay, Juan P. Arrebola, Karine Audouze, Patrick J. Babin, Robert Barouki, Amita Bansal, Etienne Blanc, Matthew C. Cave, Saurabh Chatterjee, Nicolas Chevalier, Mahua Choudhury, David Collier, Lisa Connolly, Xavier Coumoul, Gabriella Garruti, Michael Gilbertson, Lori A. Hoepner, Alison C. Holloway, George Howell, Christopher D. Kassotis, Mathew K. Kay, Min Ji Kim, Dominique Lagadic-Gossmann, Sophie Langouet, Antoine Legrand, Zhuorui Li, Helene Le Mentec, Lars Lind, P. Monica Lind, Robert H. Lustig, Corinne Martin-Chouly, Vesna Munic Kos, Normand Podechard, Troy A. Roepke, Robert M. Sargis, Anne Starling, Craig R. Tomlinson, Charbel Touma, Jan Vondracek, Frederick vom Saal, Bruce Blumberg
Přispěvatelé: Jonchère, Laurent, Healthy Environment and Endocrine Disruptor Strategies (HEEDS), Universidad de Granada = University of Granada (UGR), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Bordeaux (UB), Australian National University - Department of engineering (ANU), Australian National University (ANU), University of Louisville, University of South Carolina [Columbia], Université Côte d'Azur (UCA), Texas A&M University System, East Carolina University [Greenville] (ECU), University of North Carolina System (UNC), Queen's University [Belfast] (QUB), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), University of Stirling, State University of New York (SUNY), McMaster University [Hamilton, Ontario], Mississippi State University [Mississippi], Wayne State University [Detroit], École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of California [Irvine] (UC Irvine), University of California (UC), Uppsala Universitet [Uppsala], University of California [San Francisco] (UC San Francisco), Karolinska Institute, EHESP-Irset (EHESP-Irset), Rutgers University System (Rutgers), University of Illinois [Chicago] (UIC), University of Illinois System, University of North Carolina [Chapel Hill] (UNC), Geisel School of Medicine at Dartmouth, Institute of Biophysics of the Czech Academy of Sciences (IBP / CAS), Czech Academy of Sciences [Prague] (CAS), University of Missouri [Columbia] (Mizzou), University of Missouri System
Rok vydání: 2021
Předmět:
Zdroj: Biochemical Pharmacology
Biochemical Pharmacology, 2022, 199, pp.115015. ⟨10.1016/j.bcp.2022.115015⟩
Biochem Pharmacol.
Biochem Pharmacol
ISSN: 1873-2968
0006-2952
Popis: International audience; Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.
Databáze: OpenAIRE
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