Cortactin expression predicts poor survival in laryngeal carcinoma
Autor: | Mirjam F. Mastik, Lorian Menkema, J.E. van der Wal, Johan H. Gibcus, Ed Schuuring, Philippus Kluin, de Truuske Bock |
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Přispěvatelé: | Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Stem Cell Aging Leukemia and Lymphoma (SALL), Targeted Gynaecologic Oncology (TARGON) |
Jazyk: | angličtina |
Rok vydání: | 2008 |
Předmět: |
Adult
Male Cancer Research PROGNOSIS Fas-Associated Death Domain Protein cyclin D1 HNSCC Cyclin D1 medicine Carcinoma Humans GENE AMPLIFICATION FADD CHROMOSOME 11Q13 AMPLIFICATION CTTN EMS1 HEAD Molecular Diagnostics Laryngeal Neoplasms Lymph node NECK Aged Neoplasm Staging Aged 80 and over larynx biology ABNORMALITIES Chromosomes Human Pair 11 Cancer Middle Aged Amplicon cortactin medicine.disease Immunohistochemistry Head and neck squamous-cell carcinoma CANCER medicine.anatomical_structure 11q13 Oncology biology.protein Cancer research Regression Analysis Female CYCLIN D1 OVEREXPRESSION SQUAMOUS-CELL CARCINOMA Cortactin |
Zdroj: | British Journal of Cancer British Jounal of Cancer, 98(5), 950-955. Nature Publishing Group |
ISSN: | 0007-0920 |
Popis: | Amplification of the 11q13 region is one of the most frequent aberrations in squamous cell carcinomas of the head and neck region (HNSCC). Amplification of 11q13 has been shown to correlate with the presence of lymph node metastases and decreased survival. The 11q13.3 amplicon carries numerous genes including cyclin D1 and cortactin. Recently, we reported that FADD becomes overexpressed upon amplification and that FADD protein expression predicts for lymph node positivity and disease-specific mortality. However, the gene within the 11q13.3 amplicon responsible for this correlation is yet to be identified. In this paper, we compared, using immunohistochemical analysis for cyclin D1, FADD and cortactin in a series of 106 laryngeal carcinomas which gene correlates best with lymph node metastases and increased disease-specific mortality. Univariate Cox regression analysis revealed that high expression of cyclin D1 (P = 0.016), FADD (P = 0.003) and cortactin (P = 0.0006) predict for increased risk to disease- specific mortality. Multivariate Cox analysis revealed that only high cortactin expression correlates with disease- specific mortality independent of cyclin D1 and/or FADD. Of genes located in the 11q13 amplicon, cortactin expression is the best predictor for shorter disease-specific survival in late stage laryngeal carcinomas. |
Databáze: | OpenAIRE |
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