Acrocalyenes A and B, Two New Diterpenoids from Sinomenium acutum Associated Fungus Acrocalymma sp

Autor: Jie Liu, Ting Yang, Ya‐Hong Yuan, Jia‐Yao Hu, Li‐Bin Lin, Mei‐Li Yang, Dong‐Zhu Duan, Guo‐Wei Gong, Jian Xiao, Xiao‐Ling Wang
Rok vydání: 2022
Předmět:
Zdroj: Chemistry & Biodiversity. 19
ISSN: 1612-1880
1612-1872
Popis: We identified two new diterpenoidal acrocalyenes A (1) and B (2) through chemical investigation on Acrocalymma sp., a plant-associated fungus from the tender stem isolates of Sinomenium acutum collected from the Qinling Mountains, along with seven already-recognized compounds (3-9). The HR-ESI-TOF-MS and 1D/2D NMR data were utilized for structural elucidation of these compounds, and the single-crystal X-ray diffraction was employed for absolute configuration clarification of the novel acrocalyenes 1 and 2. Bioassays revealed that the cytotoxicities of compounds 2, 4, 6, 7, and 8 against three human carcinoma cells (RKO, HeLa and HCC-1806) were moderate to strong, with IC
Databáze: OpenAIRE
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