Schizophrenia and the gut-brain axis
| Autor: | Katlyn Nemani, Beth A. McCormick, Reza Hosseini Ghomi, Xiaoduo Fan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
biology Microbiota Gut–brain axis Brain Inflammation Immune dysregulation Gut flora medicine.disease_cause biology.organism_classification medicine.disease Gastrointestinal Tract Gluten exorphin Antigen Anti-Infective Agents Schizophrenia Immunology medicine Humans medicine.symptom Metabolic syndrome Biological Psychiatry |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 56 |
| ISSN: | 1878-4216 |
| Popis: | Several risk factors for the development of schizophrenia can be linked through a common pathway in the intestinal tract. It is now increasingly recognized that bidirectional communication exists between the brain and the gut that uses neural, hormonal, and immunological routes. An increased incidence of gastrointestinal (GI) barrier dysfunction, food antigen sensitivity, inflammation, and the metabolic syndrome is seen in schizophrenia. These findings may be influenced by the composition of the gut microbiota. A significant subgroup of patients may benefit from the initiation of a gluten and casein-free diet. Antimicrobials and probiotics have therapeutic potential for reducing the metabolic dysfunction and immune dysregulation seen in patients with schizophrenia. |
| Databáze: | OpenAIRE |
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