The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase

Autor: Marc Fellous, Pedro M. Alzari, P. Leroy, David Sassoon, D. Wolgemuth
Přispěvatelé: Immunogénétique humaine, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), lmmunologie structurale, Institut Pasteur [Paris] (IP), Génétique moléculaire du Développement, Columbia University [New York], Institut Pasteur [Paris], de TARRAGON, Marie
Jazyk: angličtina
Rok vydání: 1989
Předmět:
Male
MESH: RNA Nucleotidyltransferases
MESH: Amino Acid Sequence
MESH: Base Sequence
DEAD-box RNA Helicases
MESH: Eukaryotic Initiation Factor-4A
Mice
0302 clinical medicine
Peptide Initiation Factors
Transcription (biology)
Testis
Protein biosynthesis
MESH: Animals
MESH: Peptide Initiation Factors
[INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]
0303 health sciences
[PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Structural Biology [q-bio.BM]
MESH: Testis
MESH: RNA Helicases
MESH: Spermatozoa
MESH: DNA
RNA Nucleotidyltransferases
MESH: Transcription Factors
Biological Evolution
Spermatozoa
RNA Helicase A
MESH: Gene Expression Regulation
MESH: Protein Biosynthesis
MESH: Spermatogenesis
RNA Helicases
[SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Structural Biology [q-bio.BM]
[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
Molecular Sequence Data
Mice
Inbred Strains
MESH: Biological Evolution
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
MESH: Mice
Inbred Strains
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Complementary DNA
HSPA2
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
[CHIM.CRIS]Chemical Sciences/Cristallography
Animals
MESH: DEAD-box RNA Helicases
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Amino Acid Sequence
[CHIM.CRIS] Chemical Sciences/Cristallography
Spermatogenesis
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
MESH: Mice
030304 developmental biology
HSPA9
MESH: Molecular Sequence Data
Base Sequence
vasa gene
DNA
Molecular biology
MESH: Male
EIF4EBP1
Gene Expression Regulation
Protein Biosynthesis
Eukaryotic Initiation Factor-4A
[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]
030217 neurology & neurosurgery
Transcription Factors
Zdroj: Cell
Cell, 1989, 57 (4), pp.549-559. ⟨10.1016/0092-8674(89)90125-6⟩
Cell, Elsevier, 1989, 57 (4), pp.549-559. ⟨10.1016/0092-8674(89)90125-6⟩
ISSN: 0092-8674
1097-4172
DOI: 10.1016/0092-8674(89)90125-6⟩
Popis: International audience; The murine PL10 cDNA corresponds to a transcript expressed only in the male germ line. Its expression is developmentally regulated, with high levels of transcripts being present during the meiotic and haploid stages of spermatogenesis. The deduced protein is shown to be highly homologous to the murine translation initiation factor eIF-4A and to other proteins that are also homologous to eIF-4A, including the Drosophila protein vasa. By consensus sequence conservation and comparison of secondary structure predictions, putative mononucleotide binding and DNA/RNA binding domains are proposed to be shared by all these proteins. Taken together, these results suggest a helicase function for PL10 protein similar to that of eIF-4A and suggests its possible role in a key step of the spermatogenic process. The possible significance of the similarity between the PL10 protein and the protein product of the maternal effect gene vasa is also discussed.
Databáze: OpenAIRE
Externí odkaz: