Plasma methionine metabolic profile is associated with longevity in mammals
| Autor: | M Jové, R Berdún, N Mota-Martorell, R Pamplona |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Swine Malates Succinic Acid Medicine (miscellaneous) Choline Mice chemistry.chemical_compound Methionine 0302 clinical medicine Biology (General) Phylogeny media_common chemistry.chemical_classification biology Longevity Amino acid Biochemistry Rabbits General Agricultural and Biological Sciences Intracellular medicine.drug QH301-705.5 media_common.quotation_subject Guinea Pigs Article Gas Chromatography-Mass Spectrometry General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Cystathionine Dogs Carnitine medicine Metabolomics Animals Humans Horses Sheep Metabolism Cystathionine beta synthase Rats Ageing 030104 developmental biology chemistry Cats biology.protein Cattle 030217 neurology & neurosurgery |
| Zdroj: | Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021) Repositorio Abierto de la UdL Universitad de Lleida Communications Biology |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-021-02254-3 |
| Popis: | Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association between longevity and methionine content. The present study follows a comparative approach to analyse plasma methionine metabolic profile using a LC-MS/MS platform from 11 mammalian species with a longevity ranging from 3.5 to 120 years. Our findings demonstrate the existence of a species-specific plasma profile for methionine metabolism associated with longevity characterised by: i) reduced methionine, cystathionine and choline; ii) increased non-polar amino acids; iii) reduced succinate and malate; and iv) increased carnitine. Our results support the existence of plasma longevity features that might respond to an optimised energetic metabolism and intracellular structures found in long-lived species. Mota-Martorell and colleagues use a comparative metabolomics approach to examine plasma metabolite levels associated with methionine metabolism in 11 mammalian species. They identify species specific plasma profiles indicative of a link between lifetime longevity and methionine metabolism. |
| Databáze: | OpenAIRE |
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