Structural study of the novel lipopolysaccharide O-antigen produced by the emerging cystic fibrosis pathogen Pandoraea pulmonicola
| Autor: | Máire Callaghan, Domenico Garozzo, Michelangelo Parrilli, Luisa Sturiale, Anne Costello, Siobhán McClean, Alba Silipo, Flaviana Di Lorenzo, Antonio Molinaro, Rosa Lanzetta |
|---|---|
| Přispěvatelé: | DI LORENZO, Flaviana, Silipo, Alba, A., Costello, L., Sturiale, M., Callaghan, D., Garozzo, Lanzetta, Rosa, Parrilli, Michelangelo, S., Mcclean, Molinaro, Antonio |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Lipopolysaccharide biology Organic Chemistry Virulence Human pathogen Pandoraea pulmonicola biology.organism_classification Cystic fibrosis Carbohydrates Structure elucidation Antigens NMR spectroscopy Microbiology chemistry.chemical_compound Residue (chemistry) chemistry Biochemistry Antigen GENUS PANDORAEA ASSIGNMENT APISTA CELLS Trisaccharide Physical and Theoretical Chemistry Pathogen |
| Zdroj: | European journal of organic chemistry 2012 (2012): 2243–2240. doi:10.1002/ejoc.201200047 info:cnr-pdr/source/autori:F.Di Lorenzo, A.Silipo, A.Costello, L.Sturiale, D.Garozzo, M.Callaghan, R.Lanzetta, M.Parrilli, S.McClean, A.Molinaro/titolo:Structural Study of the Lipopolysaccharide O-Antigen Produced by the Emerging Cystic Fibrosis Pathogen Pandoraea pulmonicola/doi:10.1002%2Fejoc.201200047/rivista:European journal of organic chemistry (Print)/anno:2012/pagina_da:2243/pagina_a:2240/intervallo_pagine:2243–2240/volume:2012 |
| DOI: | 10.1002/ejoc.201200047 |
| Popis: | This is the first report on the molecular structure of the O-chain of the lipopolysaccharide produced by the emerging and highly virulent clinical isolate Pandoraea pulmonicola strain LMG 18108, an opportunistic human pathogen in cystic fibrosis patients. Monosaccharide analysis and 2D NMR spectroscopy revealed a novel polysaccharide, the structure of which consists of the trisaccharide repeating unit [->2-?-d-Quip3NAcyl-(1->4)-?-d-GalpNAc-(1->3)-?-d-GlcpNAc-1->]n. The quinovosamine residue was found to be linked by a very unusual acyl substituent, a five-membered-ring acyl residue, the 3-hydroxy-2,3-dimethyl-5-oxoprolyl group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|