Endemic Carbapenem-resistantPseudomonas aeruginosawith Acquired Metallo-β-lactamase Determinants in European Hospital
| Autor: | Claudia Bearzi, Elisabetta Edalucci, Fabrizia Gionechetti, Cristina Lagatolla, Gian Maria Rossolini, C. Monti-Bragadin, Enrico Angelo Tonin, Francesca Gombac, Lucilla Dolzani |
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| Přispěvatelé: | Lagatolla, Cristina, Tonin, ENRICO ANGELO, MONTI BRAGADIN, C, Dolzani, Lucilla, Gombac, F, Bearzi, C, Edalucci, E, Gionechetti, Fabrizia, Rossolini, Gm |
| Rok vydání: | 2004 |
| Předmět: |
Microbiology (medical)
Genotype Epidemiology medicine.medical_treatment lcsh:Medicine Drug resistance Biology medicine.disease_cause beta-Lactam Resistance lcsh:Infectious and parasitic diseases Microbiology metallo-beta-lactamase (MBL) medicine Humans bacterial lcsh:RC109-216 Clonal diversity drug resistance Pseudomonas aeruginosa lcsh:R Dispatch carbapenem-hydrolyzing beta-lactamase MDR Pseudomonas aeruginosa bacterial typing bacterial infections and mycoses University hospital Virology Random Amplified Polymorphic DNA Technique Europe multiple Infectious Diseases Carbapenems Carbapenem resistant Pseudomonas aeruginosa Beta-lactamase hospital infection Random amplified polymorphic DNA technique |
| Zdroj: | Scopus-Elsevier Emerging Infectious Diseases, Vol 10, Iss 3, Pp 535-538 (2004) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| DOI: | 10.3201/eid1003.020799 |
| Popis: | Acquired metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying bla(VIM) MBL genes were found to be widespread (approximately 20% of all P. aeruginosa isolates and 70% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either bla(VIM-1)-like or bla(VIM-2)-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings. |
| Databáze: | OpenAIRE |
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