Volumetric and positional changes of planning target volumes and organs at risk using computed tomography imaging during intensity-modulated radiation therapy for head–neck cancer: an 'old' adaptive radiation therapy approach
| Autor: | Simona Allis, Maria Grazia Ruo Redda, Alessia Reali, Silvia Maria Anglesio, Gianluca Mortellaro, Francesca Arcadipane, Sara Bartoncini |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment medicine Humans Parotid Gland Radiology Nuclear Medicine and imaging Aged Image-guided radiation therapy Neuroradiology Aged 80 and over medicine.diagnostic_test business.industry Radiotherapy Planning Computer-Assisted Head and neck cancer Ultrasound Cancer Radiotherapy Dosage Interventional radiology General Medicine Middle Aged medicine.disease Radiation therapy Spinal Cord Head and Neck Neoplasms Female Radiotherapy Intensity-Modulated Tomography Radiology Tomography X-Ray Computed business Nuclear medicine |
| Zdroj: | La radiologia medica. 119:714-720 |
| ISSN: | 1826-6983 0033-8362 |
| DOI: | 10.1007/s11547-014-0386-z |
| Popis: | This study aimed to assess, in a department of radiation oncology not equipped with in-room imaging systems, volumetric and positional changes of planning target volumes (PTVs) and organs at risk in head and neck (HN) cancer patients treated with intensity-modulated radiation therapy (IMRT), using consecutive off-board computed tomography (CT) imaging. Dosimetric aspects were not investigated.Ten patients with HN cancer underwent CT re-scanning at 3, 5, and 7 weeks. Positional changes of the PTVs and parotid glands as distances relative to the virtual isocentre were determined. The parotids glands (PGs) were re-delineated on each CT set and volume differences were computed. Anterior-posterior (AP) and latero-lateral (LL) displacements for the spinal cord at C1 and C6 level were calculated. Changes in patient body contours were evaluated by comparing the volumes within the external skin outline.Apart from two patients requiring re-planning due to substantial weight loss, our results evidenced no significant shifts of PTVs and PGs. PG volume decreased with a trend in volume reduction for the ipsilateral parotid. No significant shift of spinal cord at C1 and C6 level was detected, in either the AP or LL direction. The collected data demonstrated a trend in external skin contour volume loss.Our preliminary results reflect the literature data and indicate that an off-line adaptive RT approach is appropriate in clinical practice. |
| Databáze: | OpenAIRE |
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