| Autor: |
Yuntao Song, Yanhua Bai, Jiaxin Wang, Guohui Xu, Tianxiao Wang, Bin Zhang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Endocrine journal. |
| ISSN: |
1348-4540 |
| Popis: |
Anaplastic thyroid carcinoma (ATC) is a highly malignant tumor with invasive nature. Most patients present with locally advanced and/or distant metastatic diseases that are difficult to treat. We report a case of a previously inoperable patient with v-Raf murine sarcoma viral oncogene homolog B (BRAF) mutated ATC. After a trial of neoadjuvant Dabrafenib/Trametinib with immunotherapy, the tumor became operable, and surgical pathology indicated a pathologic complete response (pCR). We also reviewed cases from the literature that utilized neoadjuvant BRAF-directed therapy in ATCs. These cases emphasize that BRAF-and immune-directed therapy is a feasible option in patients with inoperable ATC and may lead to improved outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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