Chloroquine serum concentration and side effects: Evidence for dose-dependent kinetics
| Autor: | Folke Jansson, Yngve Bergkvist, Laila Hellström, Britta Domeij-Nyberg, Marianne Frisk-Holmberg |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Drug Dose dependent kinetics media_common.quotation_subject Pharmacology Blood serum Chloroquine Rheumatic Diseases Humans Medicine Pharmacology (medical) Adverse effect Aged media_common Dose-Response Relationship Drug business.industry Middle Aged Serum concentration Kinetics Dose–response relationship Total dose Female business medicine.drug |
| Zdroj: | Clinical Pharmacology & Therapeutics. 25:345-350 |
| ISSN: | 0009-9236 |
| DOI: | 10.1002/cpt1979253345 |
| Popis: | Serum concentrations of chloroquine were determined fluorometrically in 100 rheumatoid patients who had been treated with 0.25 gm daily for at least 2 mo. The total dose varied between 3.7 and 400 gm. No patient received more than 75 gm annually. In 15% of the patients side effects were noted. There was a relationship between serum concentrations and side effects but not with the total dose administered. Chloroquine displayed dose-dependent kinetics, which may indicate that close monitoring of serum concentrations is an aid to the safe and rational use of the drug. |
| Databáze: | OpenAIRE |
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