Prognostic Factors in Bladder Cancer:A Pathologic, Immunohistochemical, and DNA Plow-cytometric Study
| Autor: | Ivana T. Croghan, Matilla A, Croghan Ga, Antonio Lopez-Beltran, Gaeta Jf |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Pathology medicine.medical_specialty Aneuploidy Biology ABO Blood-Group System Immunoenzyme Techniques Proto-Oncogene Proteins p21(ras) Biomarkers Tumor medicine Humans Stage (cooking) Isoantigens Aged Tumor marker Carcinoma Transitional Cell Ploidies Bladder cancer Urinary bladder Cell Cycle DNA Neoplasm General Medicine Middle Aged Flow Cytometry medicine.disease Transitional cell carcinoma medicine.anatomical_structure Urinary Bladder Neoplasms Immunohistochemistry Female |
| Zdroj: | American Journal of Clinical Pathology. 102:109-114 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | Pathologic grade and stage, immunohistochemical analysis of eight cell and tumor markers, and DNA ploidy were studied in 36 cases of bladder cancer to determine the features of value in assessment of patients’ survival. Tumors of high grade and advanced stage correlated with DNA aneuploidy, whereas low grade and early stage correlated with DNA diploidy when simultaneously evaluated with survival. In addition, blood group isoantigen A correlated with DNA ploidy in deceased patients, whereas blood group isoantigen H and oncogene-related protein p21 correlated well with DNA ploidy in surviving patients. Despite the relatively small number of cases studied, these results suggest that pathologic grade and stage and immunohistochemical analysis of blood group isoantigens A and H and oncogene-related protein p21 hold additional value in the prediction of bladder cancer survival when evaluated simultaneously with DNA ploidy. |
| Databáze: | OpenAIRE |
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