Baseline levels of plasma endothelin-1 (ET-1) and changes during transfusion in thalassemic patients
| Autor: | Voravarn S. Tanphaichitr, Pravit Akarasereenont, Vip Viprakasit, Kritvikrom Durongpisitkul, Sirikul Chotewuttakorn, Suthida Kankirawatana |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Hemolytic anemia medicine.medical_specialty Blood transfusion Adolescent Anemia medicine.medical_treatment Anemia Sickle Cell Gastroenterology Hemoglobins Internal medicine Humans Medicine Blood Transfusion In patient Child Endothelin-1 business.industry Hemoglobin E beta-Thalassemia Hb-E disease Hematology medicine.disease Endothelin 1 Surgery Hemoglobinopathy Hematocrit Child Preschool Female business |
| Zdroj: | American Journal of Hematology. 70:260-262 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.10129 |
| Popis: | We studied levels of plasma endothelin-1 (ET-1) in 25 β-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 ± 2.1 pg/mL vs. 8.9 ± 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to slightly increase during the first 24 hr but significantly decline at the 7th day to levels (8.01 ± 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET-1 in patients with β-thalassemia compared to that of patients with sickle-cell anemia. Am. J. Hematol. 70:260–262, 2002.© 2002 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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