Microcephaly and ZIKA Virus: Certainty or Presumption? Systematic Review

Autor: Velásquez-Serra, Glenda Coromoto, García-Yuquilema, Camila Janina, Galarza-Cedeño, Joselyn Meylin, Preciado-Cañas, Oscar Enrique
Jazyk: angličtina
Rok vydání: 2021
Předmět:
ISSN: 0304-5412
DOI: 10.5281/zenodo.4682063
Popis: The Zika virus has been associated with microcephaly since 2015 with established links based on the epidemic in Brazil, which affected several pregnant women. The purpose of this research was to demonstrate the link between Zika virus and microcephaly, through the analysis of the characteristics related to the virus, the theories of how it enters the organism and the clinical manifestations, which lead to neurological affectations. This is a descriptive, and transversal research. The main sources of information come from studies in various medical journals, which support the proposed ideas. Some proper virus characteristics were described, as: neurotropism, the capacity to cross the placental barrier and the ability to produce degeneration of the neuroprogenitor cells, which are complement to the above-mentioned theories. Likewise, molecular alterations in the structure of the virus, allowing the virus to interfere with the brain development of fetus in pregnant women. The clinical manifestation that produces Zika virus is called Severe Congenital Syndrome which includes manifestations in the newborn, such as, morphology of the skull, brain anomalies, congenital contractures and neurological sequelae. All the damage shown have been identified, thanks to neurological examinations to newborn, neuroimaging studies, neuropathology to the cranium and its tissue
{"references": ["Torres AH, V\u00e1zquez EG, Escudero EM, Mart\u00ednez JAH, G\u00f3mez JG, Hern\u00e1ndez MS. Infecciones v\u00edricas end\u00e9micas: dengue, fiebre del Nilo y otras viriasis. Med - Programa Form M\u00e9dica Contin Acreditado [Internet]. 2018;12(57):3337-48. Available from: https://www.sciencedirect.com/science/article/pii/S0304541218301318 DOI: 10.1016/j.med.2018.05.001", "OPS/OMS. Alerta Epidemiol\u00f3gica: Infecci\u00f3n por virus Zika 7 de mayo de 2015 [Internet]. Washington, D.C. 2015 [cited January 8 2020]. Available from: https://www.paho.org/hq/index.php?option=com_content&view=article&id=10899:2015-7-may-2015-zika-virus-infection&Itemid=42346&lang=es", "Ledermann JP, Guillaumot L, Yug L, Saweyog SC, Tided M, Machieng P, et al. Aedes hensilli as a Potential Vector of Chikungunya and Zika Viruses. PLoS Negl Trop Dis [Internet]. October 9 2014;8(10):e3188. Available from: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003188 DOI: 10.1371/journal.pntd.0003188 PMID 25299181 PMCID PMC4191940", "Cabrera-Gayt\u00e1n DA, Galv\u00e1n-Hern\u00e1ndez SA. Manifestaciones cl\u00ednicas del Virus Zika. Rev Med Inst Mex Seguro Soc [Internet]. May 15 2016;54(2):225-9. Available from: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=65217 PMID 26960051", "Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, et al. Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage. PLoS Negl Trop Dis [Internet]. February 28 2012;6(2):e1477. Available from: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0001477 DOI: 10.1371/journal.pntd.0001477 PMID 22389730 PMCID: PMC3289602", "Klase ZA, Khakhina S, Schneider ADB, Callahan M V, Glasspool-Malone J, Malone R. Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. PLoS Negl Trop Dis [Internet]. August 25 2016;10(8):e0004877. Available from: https://doi.org/10.1371/journal.pntd.0004877 DOI: 10.1371/journal.pntd.0004877 PMID 27560129 PMCID PMC4999274", "Hennessey M, Fischer M, Staples JE. Zika Virus Spreads to New Areas-Region of the Americas, May 2015 - January 2016. MMWR Morb Mortal Wkly Rep 2016;65(3):55\u201358. Available from: https://www.cdc.gov/mmwr/volumes/65/wr/mm6503e1.htm DOI: 10.15585/mmwr.mm6503e1external icon PMID 26820163", "Gonz\u00e1lez Collantes SG. Situaci\u00f3n epidemiol\u00f3gica del virus zika. An Fac Med [Internet]. May 16 2017;78(1):73-8. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/13025 DOI: 10.15381/anales.v78i1.13025", "Marcondes CB, Ximenes M de FF de M. Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes. Rev Soc Bras Med Trop [Internet]. 2016;49(1):4-10. Available from: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015005003102&lng=en&nrm=iso&tlng=en DOI: 10.1590/0037-8682-0220-2015 PMID 26689277", "Magui\u00f1a Vargas C. Zika, la nueva enfermedad emergente en Am\u00e9rica. Rev Medica Hered [Internet]. 2016;27(1):3-6. Available from: http://revistas.upch.edu.pe/index.php/RMH/article/download/2776/2639", "Magui\u00f1a C, Gal\u00e1n-Rodas E. El virus Zika: una revisi\u00f3n de literatura. Acta M\u00e9dica Peru [Internet]. May 16 2016;33(1):34-41. Available from: https://amp.cmp.org.pe/index.php/AMP/article/view/16 DOI: 10.35663/amp.2016.331.16", "Schaub B, Gueneret M, Jolivet E, Decatrelle V, Yazza S, Gueye H, et al. Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series. Lancet Child Adolesc Heal [Internet]. September 1 2017;1(1):45-55. Available from: https://doi.org/10.1016/S2352-4642(17)30001-9 DOI: 10.1016/S2352-4642(17)30001-9 PMID 30169227", "Ministerio de Salud P\u00fablica del Ecuador. Respuesta frente al virus Zika en el Ecuador [Internet]. 2016 [Cited january 8 2020]. Available from: https://www.salud.gob.ec/wp-content/uploads/2015/12/RESPUESTA-FRENTE-AL-ZIKA.pdf", "Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, et al. Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication. Science [Internet]. July 7 2017;357(6346):83-8. Available from: http://science.sciencemag.org/content/357/6346/83.abstract DOI: 10.1126/science.aam9243 PMID 28572454 PMCID PMC5798584", "Gascon-Jimenez FJ, Gallardo-Hernandez FL, Fernandez-Ramos JA, Aguilar-Quintero M, Camino-Leon R, Lopez-Laso E. Microcefalia primaria hereditaria de tipo 5. No todo es virus del Zika. Rev Neurol [Internet]. February 2018;66(3):101-2. Available from: https://www.neurologia.com/articulo/2017301 DOI: 10.33588/rn.6603.2017301 PMID 29368329", "Weatherhead JE, da Silva J, Murray KO. Threat of Zika Virus to the 2016 Rio de Janeiro Olympic and Paralympic Games. Curr Trop Med Reports [Internet]. 2016;3(3):120-5. Disponible en: https://doi.org/10.1007/s40475-016-0076-0 DOI: 10.1007/s40475-016-0076-0", "Rivadeneyra-Espinar PG, Venegas-Esquivel GA, D\u00edaz-Espinoza CM, P\u00e9rez-Robles VM, Gonz\u00e1lez-Fern\u00e1ndez MI, Sesma-Medrano E. Zika como causa de aborto espont\u00e1neo en zonas end\u00e9micas. Bol Med Hosp Infant Mex [Internet]. June 13 2019;76(4):193-7. Available from: https://www.bmhim.com/frame_esp.php?id=87# DOI: 10.24875/bmhim.19000116 PMID 31303651", "Albinagorta Ol\u00f3rtegui R, D\u00edaz Vela M del P. Salud fetal y diagn\u00f3stico ultrasonogr\u00e1fico en la infecci\u00f3n perinatal por el virus zika. Rev Peru Ginecol y Obstet [Internet]. April 22 2017;63(1):71-9. Available from: http://spog.org.pe/web/revista/index.php/RPGO/article/view/1968 DOI: 10.31403/rpgo.v63i1968", "Arroyo HA. Microcefalia. Med (Buenos Aires) [Internet]. 2018;78(2):94-100. Available from: https://www.medicinabuenosaires.com/PMID/30199373.pdf PMID 30199373", "de Oliveira WK, de Fran\u00e7a GVA, Carmo EH, Duncan BB, de Souza Kuchenbecker R, Schmidt MI. Infection-related microcephaly after the 2015 and 2016 Zika virus outbreaks in Brazil: a surveillance-based analysis. Lancet [Internet]. August 26 2017;390(10097):861-70. Available from: https://doi.org/10.1016/S0140-6736(17)31368-5 DOI: 10.1016/S0140-6736(17)31368-5 PMID 28647172", "Moraes M, Sobrero H, Mayans E, Borbonet D. Infecci\u00f3n por virus Zika en el embarazo y el reci\u00e9n nacido. Arch Pediatr Urug. 2016;87(4):374-83. Available from: https://www.sup.org.uy/archivos-de-pediatria/adp87-4/web/pdf/adp87-4_pauta%20zika.pdf", "de Oliveira CS, da Costa Vasconcelos PF. Microcephaly and Zika virus. J Pediatr (Rio J) [Internet]. 2016;92(2):103-5. Available from: https://www.sciencedirect.com/science/article/pii/S0021755716000395 DOI: 10.1016/j.jped.2016.02.003 PMID 27036749", "Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika Virus Infection in Pregnant Women in Rio de Janeiro. N Engl J Med [Internet]. March 4 2016;375(24):2321-34. Available from: https://doi.org/10.1056/NEJMoa1602412 DOI: 10.1056/NEJMoa1602412 PMID 26943629 PMCID PMC5323261", "Martines RB, Bhatnagar J, de Oliveira Ramos AM, Davi HPF, Iglezias SD, Kanamura CT, et al. Pathology of congenital Zika syndrome in Brazil: a case series. Lancet [Internet]. August 27 2016;388(10047):898-904. Available from: https://doi.org/10.1016/S0140-6736(16)30883-2 DOI: 10.1016/S0140-6736(16)30883-2 PMID 27372395", "Shapiro-Mendoza CK, Rice ME, Galang RR, Fulton AC, VanMaldeghem K, Prado MV, et al. Pregnancy Outcomes After Maternal Zika Virus Infection During Pregnancy - U.S. Territories, January 1, 2016-April 25, 2017. MMWR Morb Mortal Wkly Rep [Internet]. June 2017;66(23):615-21. Available from: https://www.cdc.gov/mmwr/volumes/66/wr/mm6623e1.htm DOI: 10.15585/mmwr.mm6623e1 PMID 28617773 PMCID PMC5657842", "World Health Oranization. Zika Virus IHR Emergency Committee [Internet]. [Cited january 8 2020]. Available from: https://www.who.int/groups/zika-virus-ihr-emergency-committee", "Mlakar J, Korva M, Tul N, Popovi\u0107 M, Polj\u0161ak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med [Internet]. February 10 2016;374(10):951-8. Available from: https://doi.org/10.1056/NEJMoa1600651 DOI: 10.1056/NEJMoa1600651 PMID 26862926", "Wen Z, Song H, Ming GL. How does Zika virus cause microcephaly? [Internet]. Genes and Development. 2017;31(9):849-61. Available from: http://genesdev.cshlp.org/content/31/9/849.long DOI: 10.1101/gad.298216.117 PMID 28566536 PMCID PMC5458753", "Adiga R. Phylogenetic analysis of the NS5 gene of Zika virus. J Med Virol [Internet]. October 1 2016;88(10):1821-6. Available from: https://doi.org/10.1002/jmv.24615 DOI: 10.1002/jmv.24615 PMID 27335310", "Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, et al. Biology of Zika Virus Infection in Human Skin Cells. J Virol [Internet]. September 1 2015;89(17):8880-96. Available from: http://jvi.asm.org/content/89/17/8880.abstract DOI: 10.1128/JVI.00354-15 PMID 26085147 PMCID PMC4524089", "Raghunath P. Does Zika Virus Really Causes Microcephaly in Children Whose Mothers Became Infected with the Virus during Their Pregnancy? Iran J Public Health [Internet]. April 2018;47(4):613-4. Available from: http://ijph.tums.ac.ir/index.php/ijph/article/view/13168/5964 PMID 29900151", "Hanners NW, Eitson JL, Usui N, Richardson RB, Wexler EM, Konopka G, et al. Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects. Cell Rep [Internet]. June 14 2016;15(11):2315-22. Available from: https://doi.org/10.1016/j.celrep.2016.05.075 DOI: 10.1016/j.celrep.2016.05.075 PMID 27268504 PMCID PMC5645151", "Cavalheiro S, Lopez A, Serra S, Da Cunha A, da Costa MDS, Moron A, et al. Microcephaly and Zika virus: neonatal neuroradiological aspects. Child's Nerv Syst [Internet]. 2016;32(6):1057-60. Available from: https://doi.org/10.1007/s00381-016-3074-6 DOI: 10.1007/s00381-016-3074-6 PMID 27080092 PMCID PMC4882355", "Adibi JJ, Marques Jr ETA, Cartus A, Beigi RH. Teratogenic effects of the Zika virus and the role of the placenta. Lancet [Internet]. April 9 2016;387(10027):1587-90. Available from: https://doi.org/10.1016/S0140-6736(16)00650-4 DOI: 10.1016/S0140-6736(16)00650-4 PMID 26952548", "Coronell-Rodr\u00edguez W, Arteta-Acosta C, Su\u00e1rez-Fuentes MA, Burgos-Rolon MC, Rubio-Sotomayor MT, Sarmiento-Guti\u00e9rrez M, et al. Infecci\u00f3n por virus del Zika en el embarazo, impacto fetal y neonatal. Rev Chil Infect [Internet]. 2016;33(6):665-73. Available from: https://scielo.conicyt.cl/scielo.php?pid=S0716-10182016000600009&script=sci_arttext&tlng=n DOI: 10.4067/S0716-10182016000600009 PMID 28146192", "Li C, Xu D, Ye Q, Hong S, Jiang Y, Liu X, et al. Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell [Internet]. July 7 2016;19(1):120-6. Available from: https://doi.org/10.1016/j.stem.2016.04.017 DOI: 10.1016/j.stem.2016.10.017 PMID 27179424", "Aspilcueta-Gho D, Benites Villafane C, Calder\u00f3n S\u00e1nchez MM, Calder\u00f3n Yberico JG. Infecci\u00f3n por zika en el Per\u00fa: de amenaza a problema de salud. Rev Peru Ginecol y Obstet [Internet]. 2017;63(1):57-64. Available from: http://www.spog.org.pe/web/revista/index.php/RPGO/article/view/1965 DOI: 10.31403/rpgo.v63i1965", "Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JLM, Guimar\u00e3es KP, et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature [Internet]. 2016;534(7606):267-71. Available from: https://doi.org/10.1038/nature18296 DOI: 10.1038/nature18296 PMID 27279226 PMCID PMC4902174", "Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, et al. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc Natl Acad Sci [Internet]. December 13 2016;113(50):14408-14413. Available from: http://www.pnas.org/content/113/50/14408.abstract DOI: 10.1073/pnas.1618029113 PMID 27911847 PMCID: PMC5167169", "Calvet G, Aguiar RS, Melo ASO, Sampaio SA, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis [Internet]. June 1 2016;16(6):653-60. Available from: https://doi.org/10.1016/S1473-3099(16)00095-5 DOI: 10.1016/S1473-3099(16)00095-5 PMID 26897108", "Miner JJ, Diamond MS. Zika Virus Pathogenesis and Tissue Tropism. Cell Host Microbe [Internet]. February 8 2017;21(2):134-42. Available from: https://doi.org/10.1016/j.chom.2017.01.004 DOI: 10.1016/j.chom.2017.01.004 PMID 28182948 PMCID PMC5328190", "Xie X, Shan C, Shi P-Y. Restriction of Zika Virus by Host Innate Immunity. Cell Host Microbe [Internet]. May 11 2016;19(5):566-7. Available from: https://doi.org/10.1016/j.chom.2016.04.019 DOI: 10.1016/j.chom.2016.04.019 PMID 27173920", "Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques Jr. ETDA, et al. Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell Host Microbe [Internet]. 11 de mayo de 2016;19(5):705-12. Available from: https://doi.org/10.1016/j.chom.2016.03.008 DOI: 10.1016/j.chom.2016.03.008 PMID 27066743 PMCID PMC4866896", "Adibi JJ, Zhao Y, Cartus AR, Gupta P, Davidson LA. Placental Mechanics in the Zika-Microcephaly Relationship. Cell Host Microbe [Internet]. July 13 2016;20(1):9-11. Available from: https://doi.org/10.1016/j.chom.2016.06.013 DOI: 10.1016/j.chom.2016.06.013 PMID 27414496", "Lazear HM, Diamond MS. Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere. J Virol [Internet]. May 15 2016;90(10):4864-4875. Available from: http://jvi.asm.org/content/90/10/4864.abstract DOI: 10.1128/JVI.00252-16 PMID 26962217 PMCID PMC4859708", "Russo FB, Jungmann P, Beltr\u00e3o-Braga PCB. Zika infection and the development of neurological defects. Cell Microbiol [Internet]. June 1 2017;19(6):e12744. Available from: https://doi.org/10.1111/cmi.12744 DOI: 10.1111/cmi.12744 PMID 28370966", "Liang Q, Luo Z, Zeng J, Chen W, Foo S-S, Lee S-A, et al. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell [Internet]. 2016;19(5):663-71. Available from: https://www.sciencedirect.com/science/article/pii/S1934590916302144 DOI: 10.1016/j.stem.2016.07.019 PMID 27524440 PMCID PMC5144538", "Lugones Botell M, Ram\u00edrez Berm\u00fadez M. Infecci\u00f3n por virus zika en el embarazo y microcefalia. Rev Cuba Obstet y Ginecol [Internet]. 2016;42(3):398-411. Available from: http://www.revginecobstetricia.sld.cu/index.php/gin/article/view/83", "Sarno M, Aquino M, Pimentel K, Cabral R, Costa G, Bastos F, et al. Progressive lesions of central nervous system in microcephalic fetuses with suspected congenital Zika virus syndrome. Ultrasound Obstet Gynecol [Internet]. Decembre 1 2017;50(6):717-22. Available from: https://doi.org/10.1002/uog.17303 DOI: 10.1002/uog.17303 PMID 27644020", "Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo de Filippis AM. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol [Internet]. January 1 2016;47(1):6-7. Available from: https://doi.org/10.1002/uog.15831 DOI: https://doi.org/10.1002/uog.15831 PMID 26731034", "Qian X, Nguyen HN, Song MM, Hadiono C, Ogden SC, Hammack C, et al. Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell [Internet]. May 19 2016;165(5):1238-54. Available from: https://doi.org/10.1016/j.cell.2016.04.032 DOI: 10.1016/j.cell.2016.04.032 PMID 27118425 PMCID PMC4900885", "Satterfield-Nash A, Kotzky K, Allen J, Bertolli J, Moore CA, Pereira IO, et al. Health and Development at Age 19-24 Months of 19 Children Who Were Born with Microcephaly and Laboratory Evidence of Congenital Zika Virus Infection During the 2015 Zika Virus Outbreak - Brazil, 2017. MMWR Morb Mortal Wkly Rep [Internet]. December 2017;66(49):1347-51. Available from: https://www.cdc.gov/mmwr/volumes/66/wr/mm6649a2.htm DOI: 10.15585/mmwr.mm6649a2 PMID 29240727 PMCID PMC5730218", "Yale School of Medicine. Findings Shed New Light On Why Zika Causes Birth Defects In Some Pregnancies [Internet]. 2019 [Cited November 15 2019]. Available from: https://medicine.yale.edu/news-article/21037/", "Parmar H, Ibrahim M. Pediatric Intracranial Infections. Neuroimaging Clin N Am [Internet]. 2012;22(4):707-25. Available from: https://www.sciencedirect.com/science/article/pii/S1052514912000846 DOI: 10.1016/j.nic.2012.05.016 PMID 23122263", "van der Linden V, Pessoa A, Dobyns W, Barkovich AJ, van der Linder H, Rolim EL, et al. Description of 13 Infants Born During October 2015-January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth-Brazil. MMWR Morb Mortal Wkly Rep [Internet]. December 2016;65(47):1343-8. Available from: https://www.cdc.gov/mmwr/volumes/65/wr/mm6547e2.htm DOI: 10.15585/mmwr.mm6547e2 PMID 27906905", "Yepez JB, Murati FA, Pettito M, Pe\u00f1aranda CF, de Yepez J, Maestre G, et al. Ophthalmic Manifestations of Congenital Zika Syndrome in Colombia and Venezuela. JAMA Ophthalmol [Internet]. May 1 2017;135(5):440-5. Available from: https://doi.org/10.1001/jamaophthalmol.2017.0561 DOI: 10.1001/jamaophthalmol.2017.0561 PMID 28418539 PMCID PMC5470423", "Ventura C V, Maia M, Travassos SB, Martins TT, Patriota F, Nunes ME, et al. Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection. JAMA Ophthalmol [Internet]. August 1 2016;134(8):912-8. Available from: https://doi.org/10.1001/jamaophthalmol.2016.1784 DOI: 10.1001/jamaophthalmol.2016.1784 PMID 27228275", "Roach T, Alcendor DJ. Zika virus infection of cellular components of the blood-retinal barriers: implications for viral associated congenital ocular disease. J Neuroinflammation [Internet]. 2017;14(1):43. Available from: https://doi.org/10.1186/s12974-017-0824-7 DOI: 10.1186/s12974-017-0824-7 PMID 28253931 PMCID PMC5335843", "Ventura C V, Maia M, Ventura B V, Linden V Van Der, Ara\u00fajo EB, Ramos RC, et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol [Internet]. 2016;79(1):1-3. Available from: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492016000100002&lng=en&nrm=iso&tlng=en PMID 26840156", "de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, et al. Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmol [Internet]. May 1 2016;134(5):529-35. Available from: https://doi.org/10.1001/jamaophthalmol.2016.0267 DOI: 10.1001/jamaophthalmol.2016.0267 PMID 26865554 PMCID PMC5444996", "Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, Kriegstein AR. Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell Stem Cell [Internet]. 2016;18(5):591-6. Available from: https://www.sciencedirect.com/science/article/pii/S1934590916001181 DOI: 10.1016/j.stem.2016.03.012 PMID 27038591 PMCID PMC4860115", "Averill LW, Kandula VVR, Akyol Y, Epelman M. Fetal Brain Magnetic Resonance Imaging Findings In Congenital Cytomegalovirus Infection With Postnatal Imaging Correlation. Semin Ultrasound, CT MRI [Internet]. 2015;36(6):476-86. Available from: https://www.sciencedirect.com/science/article/pii/S0887217115000244 DOI: 10.1053/j.sult.2015.04.001 PMID 26614131", "Microcephaly Epidemic Research Group. Microcephaly in Infants, Pernambuco State, Brazil, 2015. Emerg Infect Dis [Internet]. June 2016;22(6):1090-3. Available from: https://wwwnc.cdc.gov/eid/article/22/6/16-0062_article DOI: 10.3201/eid2206.160062 PMID 27071041 PMCID PMC4880105", "Soares de Oliveira-Szejnfeld P, Levine D, Melo AS de O, Amorim MMR, Batista AGM, Chimelli L, et al. Congenital Brain Abnormalities and Zika Virus: What the Radiologist
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