Effect of nabumetone (BRL 14777), a new anti-inflammatory drug, on human platelet reactivity ex vivo: comparison with naproxen
| Autor: | P. D. Chamberlain, Barbara Nunn |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Blood Platelets Male Drug Naproxen Epinephrine Platelet Aggregation medicine.drug_class media_common.quotation_subject Anti-Inflammatory Agents Pharmaceutical Science Arachidonic Acids Pharmacology Anti-inflammatory chemistry.chemical_compound Nabumetone Platelet Adhesiveness medicine Humans Reactivity (chemistry) Platelet media_common Arachidonic Acid Adenosine Diphosphate Adenosine diphosphate chemistry Female Collagen Ex vivo medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 34:576-579 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1982.tb04796.x |
| Popis: | The effect of nabumetone (BRL 14777) on human platelet reactivity ex vivo was compared with that of naproxen at equitherapeutic doses in the same six subjects. Nabumetone had only a weak and equivocal effect on collagen-induced and second phase aggregation in response to adenosine diphosphate and adrenaline. After nabumetone, platelets fully aggregated in response to sodium arachidonate, though approximately twice as much was needed as on control occasions. Sodium arachidonate was unable to elicit a full aggregation response after naproxen. These results suggest that nabumetone may cause less interference with haemostasis than other non-steroidal anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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