Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy
| Autor: | Valeriia Mikhailova, Vladlena Tiasto, Artem Blagodatski, Alexander Kagansky, Margarita Yatsunskaya, Vladimir L. Katanaev |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Folk medicine fungotherapy medicinal mushrooms business.industry biomedicine Cancer therapy Cancer Review Biology medicine.disease Cancer treatment Biotechnology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine targeted treatment Oncology 030220 oncology & carcinogenesis medicine cancer business |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.25660 |
| Popis: | Medicinal mushrooms have been used throughout the history of mankind for treatment of various diseases including cancer. Nowadays they have been intensively studied in order to reveal the chemical nature and mechanisms of action of their biomedical capacity. Targeted treatment of cancer, non-harmful for healthy tissues, has become a desired goal in recent decades and compounds of fungal origin provide a vast reservoir of potential innovational drugs. Here, on example of four mushrooms common for use in Asian and Far Eastern folk medicine we demonstrate the complex and multilevel nature of their anticancer potential, basing upon different groups of compounds that can simultaneously target diverse biological processes relevant for cancer treatment, focusing on targeted approaches specific to malignant tissues. We show that some aspects of fungotherapy of tumors are studied relatively well, while others are still waiting to be fully unraveled. We also pay attention to the cancer types that are especially susceptible to the fungal treatments. |
| Databáze: | OpenAIRE |
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