Chronic smoking and cognition in patients with schizophrenia: A meta-analysis
| Autor: | Bruno Romeo, Amine Benyamina, Catherine Martelli, Marine Brunet-Lecomte, Amélie Petillion, Nicolas Coustals |
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| Přispěvatelé: | Hôpital Paul Brousse, Neuroimagerie en psychiatrie (U1000), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Digitéo, Université Paris-Saclay, CCSD, Accord Elsevier, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11) |
| Rok vydání: | 2020 |
| Předmět: |
[SDV]Life Sciences [q-bio]
media_common.quotation_subject Population PsycINFO Neuropsychological Tests 03 medical and health sciences Cognition 0302 clinical medicine Tobacco mental disorders medicine Humans education Biological Psychiatry media_common education.field_of_study business.industry Addiction Smoking medicine.disease 030227 psychiatry [SDV] Life Sciences [q-bio] Meta-analysis Psychiatry and Mental health Memory Short-Term Schizophrenia business Neurocognitive 030217 neurology & neurosurgery Clinical psychology Diagnosis of schizophrenia |
| Zdroj: | Schizophrenia Research Schizophrenia Research, Elsevier, 2020, 222, pp.113-121. ⟨10.1016/j.schres.2020.03.071⟩ Schizophrenia Research, 2020, 222, pp.113-121. ⟨10.1016/j.schres.2020.03.071⟩ |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2020.03.071 |
| Popis: | International audience; Background: Patients with schizophrenia display a very high rate of smoking in comparison with the general population. The aim of the present meta-analysis was to assess the association between cognitive performances and smoking status in patients with schizophrenia.Methods: This review was registered at PROSPERO, number CRD42019126758. After a systematic search on MEDLINE, PsycINFO, and clinicaltrials.gov databases, all studies measuring neurocognitive performances in both smoking and nonsmoking patients with a diagnosis of schizophrenia were included. Original data were extracted. Standardized mean differences (SMD) were calculated with the means and standard deviations extracted using a random-effect model. Cognitive performances were compared between smoking and nonsmoking patients with schizophrenia. Meta-regressions were performed to explore the influence of sociodemographic and clinical variables on SMD.Results: Eighteen studies were included in this meta-analysis. Chronic smoking in patients with schizophrenia, compared to nonsmoking, was associated with a significant more important impairment in attention (p = 0.02), working memory (p < 0.001), learning (p < 0.001), executive function (EF) reasoning/problem solving (p < 0.001) and speed of processing (p < 0.001), but not in delayed memory, EF abstraction/shifting, EF inhibition and language. The meta-regression analysis found that attention impairment could be influenced by age (p < 0.001) and Positive and Negative Syndrome Scale (PANSS) total score (p = 0.006).Conclusions: This meta-analysis provides strong evidence that, in patients with schizophrenia, chronic smoking is related to cognitive impairment. This association emphasizes the importance of paying careful attention to both tobacco addiction and cognitive functioning in patients with schizophrenia. |
| Databáze: | OpenAIRE |
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