The role of the O-antigen lipopolysaccharide and capsule on an experimental Klebsiella pneumoniae infection of the rat urinary tract
| Autor: | V J Benedí, Juan M. Tomás, Silvia Camprubi, Susana Merino |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Klebsiella
Lipopolysaccharide Klebsiella pneumoniae Urinary Bladder Kidney Polysaccharide Microbiology chemistry.chemical_compound Antigen Cystitis Genetics Animals Rats Wistar Molecular Biology Infectivity chemistry.chemical_classification Antigens Bacterial Pyelonephritis biology Polysaccharides Bacterial Urinary Bladder Diseases O Antigens biology.organism_classification Enterobacteriaceae Klebsiella Infections Rats chemistry Antigens Surface Urinary Tract Infections Electrophoresis Polyacrylamide Gel Female Kidney Diseases Bacteria |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0378-1097 |
| DOI: | 10.1016/0378-1097(93)90175-2 |
| Popis: | We obtained, by different methods, isogenic lipopolysaccharide (O antigen) and capsular polysaccharide (K antigen) mutants from Klebsiella pneumoniae strains able to induce experimental infections (cystitis and pyelonephritis) in rats. We compared the induction of experimental infections in rats by wild-type strains and the lipopolysaccharide and capsular polysaccharide mutants. The high-molecular mass lipopolysaccharide of K. pneumoniae is clearly implicated in the infection process of the rat urinary tract, whilst the capsular polysaccharide seems not to be involved to the same extent. |
| Databáze: | OpenAIRE |
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