Strain-level analysis of mother-to-child bacterial transmission during the first few months of life
| Autor: | Pamela Ferretti, Hera Vlamakis, Surya Tripathi, Edoardo Pasolli, Ramnik J. Xavier, Heikki Hyöty, Mikael Knip, Heli Siljander, Sami Oikarinen, Suvi M. Virtanen, Eeva Jason, Eric S. Lander, Jorma Ilonen, Curtis Huttenhower, Nicola Segata, Francesco Asnicar, Moran Yassour, Adrian Tett, Timothy D. Arthur, Larson Hogstrom, Jenni Selvenius |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics, Yassour, Moran, Jason, Eeva, Hogstrom, Larson J., Arthur, Timothy D., Tripathi, Surya, Siljander, Heli, Selvenius, Jenni, Oikarinen, Sami, Hyöty, Heikki, Virtanen, Suvi M., Ilonen, Jorma, Ferretti, Pamela, Pasolli, Edoardo, Tett, Adrian, Asnicar, Francesco, Segata, Nicola, Vlamakis, Hera, Lander, Eric S., Huttenhower, Curti, Knip, Mikael, Xavier, Ramnik J. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
DNA Bacterial Male Meconium Mother-Child Relation 0301 basic medicine Physiology Mothers Longitudinal Studie Drug resistance Biology Microbiology Article Bacterial genetics Metagenomic 03 medical and health sciences Virology Drug Resistance Bacterial Inheritance Patterns Humans Colonization Transmission (medicine) Incidence (epidemiology) Strain (biology) Microbiota Infant Newborn Infant ta3123 Infectious Disease Transmission Vertical 3. Good health Gastrointestinal Microbiome Gastrointestinal Tract Prospective Studie Bacteroide 030104 developmental biology Fece Parasitology Female Cohort Studie Human Cohort study |
| Zdroj: | PMC |
| Popis: | Bacterial community acquisition in the infant gut impacts immune education and disease susceptibility. We compared bacterial strains across and within families in a prospective birth cohort of 44 infants and their mothers, sampled longitudinally in the first months of each child's life. We identified mother-to-child bacterial transmission events and describe the incidence of family-specific antibiotic resistance genes. We observed two inheritance patterns across multiple species, where often the mother's dominant strain is transmitted to the child, but occasionally her secondary strains colonize the infant gut. In families where the secondary strain of B. uniformis was inherited, a starch utilization gene cluster that was absent in the mother's dominant strain was identified in the child, suggesting the selective advantage of a mother's secondary strain in the infant gut. Our findings reveal mother-to-child bacterial transmission events at high resolution and give insights into early colonization of the infant gut. Using longitudinal metagenomic sequencing from 44 mother/child pairs, Yassour et al. characterized mother-to-child strain transmission patterns. While mothers' dominant strains were often inherited, nondominant secondary strain transmissions were also observed. Microbial functional analysis reveals that inherited maternal secondary strains may have a selective advantage to colonize infant guts. National Institutes of Health (Grant 1DP3DK094338–01) |
| Databáze: | OpenAIRE |
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