Functional Outcomes and Complications After Salvage Total Laryngectomy for Residual, Recurrent, and Second Primary Squamous Cell Carcinoma of the Larynx and Hypopharynx: A Multicenter Retrospective Cohort Study
| Autor: | Jeroen Meulemans, Hannelore Demarsin, Jens Debacker, Gaël Batailde, Tillo Mennes, Annouschka Laenen, Ann Goeleven, Peter Neyt, Christophe Vanclooster, Tom Vauterin, Pierre Delaere, Wouter Huvenne, Vincent Vander Poorten |
|---|---|
| Přispěvatelé: | Supporting clinical sciences, Nuclear Medicine, Faculty of Medicine and Pharmacy |
| Rok vydání: | 2020 |
| Předmět: |
squamous cell carcinoma
0301 basic medicine Larynx Cancer Research medicine.medical_specialty recurrence complications salvage surgery PECTORALIS MAJOR FLAP SURGERY Fistula medicine.medical_treatment Pharyngocutaneous Fistula PHARYNGOCUTANEOUS FISTULA lcsh:RC254-282 CHEMORADIATION 03 medical and health sciences 0302 clinical medicine QUALITY-OF-LIFE Medicine and Health Sciences medicine POSTOPERATIVE COMPLICATIONS Original Research larynx Science & Technology business.industry hypopharynx total laryngectomy Retrospective cohort study lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Dysphagia Surgery Laryngectomy Radiation therapy functional outcomes 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis RISK-FACTORS RADIATION medicine.symptom Complication business Life Sciences & Biomedicine ORGAN PRESERVATION THERAPY RADIOTHERAPY |
| Zdroj: | FRONTIERS IN ONCOLOGY Frontiers in Oncology, Vol 10 (2020) Frontiers in Oncology |
| ISSN: | 2234-943X |
| Popis: | Background/Purpose: We analyzed complications and functional outcomes and aimed at identifying prognostic factors for functional outcomes and complications in patients who underwent salvage total laryngectomy (STL) for residual, recurrent, and second primary squamous cell carcinoma (SCC) of the larynx and hypopharynx after initial (chemo)radiation. Methods: Retrospective cohort study of patients who underwent STL in four major Belgian reference hospitals between 2002 and 2018. Prognostic factors for functional outcomes and complications were identified with uni- and multivariable analysis. Results: A total of 405 patients were included in the final analysis. STL was performed for residual tumor (40.2%), local recurrence (40.5%), or second primary laryngeal or hypopharyngeal SCC (19.4%). Early postoperative complications were experienced by 34.2% of patients: postoperative hemorrhage occurred in 5.4%, wound infection in 16.2%, and clinical pharyngocutaneous fistula (PCF) in 25.5% of patients. Early readmission proved necessary in 15.1% of cases, most often due to late PCF development (72.2%). Patients achieved total peroral intake in 94.2% of cases. However, subjective dysphagia was reported by 31.3% of patients during follow-up. Functional speech, defined as functional communication by speech without additional aids, was reported in 86.7% of cases and was most often achieved by tracheo-esophageal puncture (TEP) (94.1%). In a multivariable model, lower preoperative hemoglobin ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|