High-dose chemotherapy and stem-cell rescue for salvage therapy for relapsed malignant mixed ovarian germ cell tumor: A case report
| Autor: | Raymond W. Redline, Sarah Sears, Sareena Singh, Kimberly Resnick, Hadi Shojaei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Yolk sac tumor medicine.medical_treatment Salvage therapy Case Report Disease Stem cell rescue lcsh:Gynecology and obstetrics lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Ovarian cancer Internal medicine Malignant Ovarian Germ Cell Tumor Medicine 030212 general & internal medicine lcsh:RG1-991 Chemotherapy business.industry Obstetrics and Gynecology medicine.disease Debulking lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030220 oncology & carcinogenesis Germ cell tumors Stem cell business |
| Zdroj: | Gynecologic Oncology Reports, Vol 22, Iss C, Pp 72-74 (2017) Gynecologic Oncology Reports |
| ISSN: | 2352-5789 |
| Popis: | Background Malignant ovarian germ cell tumors are rare, and often treatable with surgery and chemotherapy. Few data are available for treatment of platinum-resistant tumors. Case A 31 year old gravida 0 with a 20 cm pelvic mass was found to have a malignant ovarian germ cell tumor after she underwent debulking surgery. She initially responded to chemotherapy; however her AFP began to rise before all cycles were completed. She underwent additional debulking surgery that was again suboptimal. She was then referred for salvage therapy with high-dose chemotherapy with stem cell transplant, which was successful and she has had no evidence of disease for over two years. Conclusion High-dose chemotherapy with stem cell transplant is a viable salvage therapy for patients with platinum-resistant germ cell tumors. Highlights • Malignant ovarian germ cell tumors are rare. • These tumors are often treatable with surgery and adjuvant chemotherapy. • High-dose chemotherapy and stem cell rescue should be considered for platinum-resistant disease. |
| Databáze: | OpenAIRE |
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