Familial early onset frontotemporal dementia caused by a novel S356T MAPT mutation, initially diagnosed as schizophrenia
| Autor: | Tamas Revesz, M M Wickremaratchi, Huw R. Morris, Richard Arnold, Roger Beer, Parastoo Momeni, John Hardy, Jason Bell, James Neal |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Proband Pathology medicine.medical_specialty Psychosis Prefrontal Cortex tau Proteins Degenerative disease mental disorders medicine Humans Phosphorylation business.industry Parkinsonism Brain Neurofibrillary Tangles DNA General Medicine Frontotemporal lobar degeneration medicine.disease Chromosome 17 (human) Schizophrenia Frontotemporal Dementia Mutation Female Schizophrenic Psychology Surgery Neurology (clinical) business Neuroscience Chromosomes Human Pair 17 Frontotemporal dementia |
| Zdroj: | Clinical Neurology and Neurosurgery. 112:917-920 |
| ISSN: | 0303-8467 |
| Popis: | Autosomal dominant frontotemporal dementia (FTD) due to mutations in the MAPT gene is referred to as FTD with parkinsonism linked to chromosome 17 with tau pathology (FTDP-17T). Typically the disease begins in the sixth decade of life. We report a novel exon 12 mutation in MAPT (S356T), in a family with an exceptionally early age at onset (27 and 29 years), causing familial behavioural variant frontotemporal dementia. Both the proband and the proband's father were initially diagnosed as having schizophrenia. Pathological examination showed frontotemporal lobar degeneration with extensive neuronal and glial tau deposition. This mutation is one of a small group of MAPT mutations (including P301S, G335V and S352L) that cause very early onset FTDP-17T. It is likely that the early age at onset reflects a marked pathogenic effect of the mutation involving a disturbance of microtubule binding, tau phosphorylation or a major acceleration of tau aggregation. |
| Databáze: | OpenAIRE |
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