Multi‐observer contouring of male pelvic anatomy: Highly variable agreement across conventional and emerging structures of interest

Autor:	Peter B. Greer, Martin A. Ebert, Alycea McGrath, James W. Denham, John H L Matthews, Michele Krawiec, Jason Dowling, Sean Bydder, Rohen White, D. Roach, Karen Lim, Hendrick Tan, Jeremiah de Leon, Angel Kennedy, Megan Berry, Robba Rai, Jeremy D Croker, Robert Jan Smeenk, Lois Holloway, Michael G Jameson
Rok vydání:	2019
Předmět:	Male Membranous urethra Intraclass correlation Rectum Pelvis 030218 nuclear medicine & medical imaging 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Prostate medicine Humans Trigone of urinary bladder Radiology Nuclear Medicine and imaging Observer Variation Contouring Pelvic floor business.industry Radiotherapy Planning Computer-Assisted Prostatic Neoplasms Neurovascular bundle Magnetic Resonance Imaging medicine.anatomical_structure Oncology Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] 030220 oncology & carcinogenesis Anatomic Landmarks Tomography X-Ray Computed Nuclear medicine business
Zdroj:	Journal of Medical Imaging and Radiation Oncology, 63, 264-271 Journal of Medical Imaging and Radiation Oncology, 63, 2, pp. 264-271
ISSN:	1754-9485 1754-9477
DOI:	10.1111/1754-9485.12844
Popis:	Introduction This study quantified inter-observer contouring variations for multiple male pelvic structures, many of which are of emerging relevance for prostate cancer radiotherapy progression and toxicity response studies. Methods Five prostate cancer patient datasets (CT and T2-weighted MR) were distributed to 13 observers for contouring. CT structures contoured included the clinical target volume (CTV), seminal vesicles, rectum, colon, bowel bag, bladder and peri-rectal space (PRS). MR contours included CTV, trigone, membranous urethra, penile bulb, neurovascular bundle and multiple pelvic floor muscles. Contouring variations were assessed using the intraclass correlation coefficient (ICC), Dice similarity coefficient (DSC), and multiple additional metrics. Results Clinical target volume (CT and MR), bladder, rectum and PRS contours showed excellent inter-observer agreement (median ICC = 0.97; 0.99; 1.00; 0.95; 0.90, DSC = 0.83 ± 0.05; 0.88 ± 0.05; 0.93 ± 0.03; 0.81 ± 0.07; 0.80 ± 0.06, respectively). Seminal vesicle contours were more variable (ICC = 0.75, DSC = 0.73 ± 0.14), while colon and bowel bag contoured volumes were consistent (ICC = 0.97; 0.97), but displayed poor overlap (DSC = 0.58 ± 0.22; 0.67 ± 0.21). Smaller MR structures showed significant inter-observer variations, with poor overlap for trigone, membranous urethra, penile bulb, and left and right neurovascular bundles (DSC = 0.44 ± 0.22; 0.41 ± 0.21; 0.66 ± 0.21; 0.16 ± 0.17; 0.15 ± 0.15). Pelvic floor muscles recorded moderate to strong inter-observer agreement (ICC = 0.50-0.97), although large outlier variations were observed. Conclusions Inter-observer contouring variation was significant for multiple pelvic structures contoured on MR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7614d785d4af6babc6854cbf538b9116 https://doi.org/10.1111/1754-9485.12844 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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