ε‐Aminocaproic acid versus tranexamic acid in children undergoing complex cranial vault reconstruction for repair of craniosynostosis
| Autor: | Alexandra J. Borst, Christopher M Bonfield, Chi H. Le, Jenna H. Sobey, Poornachanda S. Deenadayalan, Srijaya K Reddy, Meng Xu |
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| Rok vydání: | 2021 |
| Předmět: |
Antifibrinolytic
Blood transfusion medicine.drug_class medicine.medical_treatment Population Blood Loss Surgical Craniosynostosis Craniosynostoses 03 medical and health sciences 0302 clinical medicine Antifibrinolytic agent medicine Humans Child education Retrospective Studies education.field_of_study business.industry Retrospective cohort study Hematology medicine.disease Antifibrinolytic Agents Tranexamic Acid Oncology 030220 oncology & carcinogenesis Anesthesia Aminocaproic Acid Pediatrics Perinatology and Child Health Aminocaproic acid business Tranexamic acid 030215 immunology medicine.drug |
| Zdroj: | Pediatric Blood & Cancer. 68 |
| ISSN: | 1545-5017 1545-5009 |
| Popis: | Complex cranial vault reconstruction (CCVR) for pediatric craniosynostosis is a high blood loss surgery, for which antifibrinolytic agents have been shown to reduce bleeding and transfusion requirements. The relative efficacy of ε-aminocaproic acid (EACA) versus tranexamic acid (TXA) has not yet been evaluated in this population. The aim of this retrospective study was to compare perioperative blood loss and transfusion in CCVR patients receiving EACA versus TXA. In a CCVR cohort of 95 children, 47 received EACA and 48 received TXA. We found no differences in demographics, adverse outcomes, calculated blood loss (CBL), or transfusion requirements between the two antifibrinolytic groups. |
| Databáze: | OpenAIRE |
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