Absence of Microsatellite Instability and Lack of Evidence for Subclone Diversification in the Pathogenesis and Progression of Mycosis Fungoides
| Autor: | José A.A. Sanchez, Peter Walden, Tanja C Fischer, Ansgar Lukowsky, Wolfram Sterry, Chalid Assaf, Pierluigi Amerio, Konrad Kölble |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms Dermatology Disease Biology DNA Mismatch Repair Biochemistry Pathogenesis Mycosis Fungoides medicine Humans Longitudinal Studies Molecular Biology Aged Aged 80 and over Chromosome Aberrations Mycosis fungoides Cutaneous T-cell lymphoma Microsatellite instability DNA Neoplasm Cell Biology Middle Aged Prognosis medicine.disease Phenotype Peripheral T-cell lymphoma Case-Control Studies Disease Progression Female Microsatellite Instability DNA mismatch repair Microsatellite Repeats |
| Zdroj: | Journal of Investigative Dermatology. 127:1752-1761 |
| ISSN: | 0022-202X |
| DOI: | 10.1038/sj.jid.5700793 |
| Popis: | Mutator phenotypes with microsatellite instability (MSI) correlated with defects in the mismatch repair system are characteristic for a subset of solid neoplasms, but are rare in non-Hodgkin lymphomas. In mismatch repair-deficient mice, however, mutator-type non-Hodgkin lymphomas are the most frequent tumors. To determine the role of MSI in mycosis fungoides, we compared the states of the eight dinucleotide microsatellite loci DXS418, DXS453, DXS556, DXS1060, D1S201, D6S260, D9S162, and D10S215 in tumor cells of 12 well-characterized patients at early- and advanced-stage diseases to matched healthy tissue. We did not find any MSI, although all but one patient had progressed to advanced-stage disease within the timeframe of the study. Concordantly, the expression of mismatch repair genes was normal. These results suggest that progressive accumulation of mutations as detected by MS analysis does not play a major role in the pathogenesis or in the progression of mycosis fungoides. |
| Databáze: | OpenAIRE |
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