Adiposity in relation to colorectal adenomas and hyperplastic polyps in women
| Autor: | Amanda J. Cross, Arthur Schatzkin, Michael F. Leitzmann, Brooks D. Cash, Andrew Flood, Philip Schoenfeld, Leah M. Ferrucci |
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| Rok vydání: | 2009 |
| Předmět: |
Adenoma
Adult Oncology Cancer Research medicine.medical_specialty genetic structures Colorectal cancer Rectum Colorectal adenoma Article Body Mass Index Risk Factors Internal medicine Odds Ratio otorhinolaryngologic diseases Humans Medicine Obesity neoplasms Adiposity Aged Hyperplasia business.industry Intestinal Polyps Odds ratio Middle Aged medicine.disease digestive system diseases surgical procedures operative medicine.anatomical_structure Hyperplastic Polyp Female Colorectal Neoplasms business Body mass index |
| Zdroj: | Cancer Causes & Control. 20:1497-1507 |
| ISSN: | 1573-7225 0957-5243 |
| Popis: | To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps.We conducted a cross-sectional study among 1,420 asymptomatic women aged 40-79 years who had undergone complete colonoscopy. Logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals (CI) of adenomas and hyperplastic polyps.We identified 953 women (67.1%) with no polyps, 292 (20.6%) with adenomas, and 175 (12.3%) with hyperplastic polyps. Among those with polyps, 75 women (5.3% of total women) were classified as having both adenomas and hyperplastic polyps. After adjusting for potential risk factors for colorectal cancer, BMI was related to increased risk of adenomas (OR comparing obese to normal weight women = 1.57; 95% CI = 1.07-2.29). Further, BMI was associated with enhanced risk of hyperplastic polyps (OR = 3.76; 95% CI = 2.35-6.01) and the combination of adenomas and hyperplastic polyps (OR = 2.84; 95% CI = 1.41-5.72).Excess body mass is positively related to colorectal adenomas and hyperplastic polyps, particularly when both kinds of polyps are present in combination. Future studies should continue to delineate the possible differences in potential risk factors between colorectal adenomas and hyperplastic polyps. Such work should help further elucidate the possible causes of colorectal cancer. |
| Databáze: | OpenAIRE |
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