Autologous peripheral retinal pigment epithelium translocation in patients with subfoveal neovascular membranes
| Autor: | R. W. A. M. Kuijpers, J. C. Van Meurs, Cornelia M. Mooy, T Boks, E ter Averst, Leo J. Hofland, Peter Stalmans, P. M. van Hagen, G. S. Baarsma |
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| Přispěvatelé: | Cell biology, Internal Medicine, Immunology, Pathology, Ophthalmology |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Proliferative vitreoretinopathy genetic structures Cell Transplantation medicine.medical_treatment Visual Acuity Vitrectomy Clinical Science - Extended Reports Macular Degeneration Cellular and Molecular Neuroscience chemistry.chemical_compound Ophthalmology Cell Adhesion medicine Humans Prospective Studies Pigment Epithelium of Eye Aged Aged 80 and over Retina Retinal pigment epithelium business.industry Retinal detachment Retinal Macular degeneration medicine.disease Choroidal Neovascularization eye diseases Sensory Systems Treatment Outcome medicine.anatomical_structure Choroidal neovascularization chemistry Female sense organs medicine.symptom business Follow-Up Studies |
| Zdroj: | British Journal of Ophthalmology, 88, 110-113. BMJ Publishing Group |
| ISSN: | 0007-1161 |
| Popis: | Aim: To evaluate the possibility of translocating autologous peripheral retinal pigment epithelial (RPE) cells and enhance their adhesion to improve functional outcome after choroidal neovascular membrane extraction in patients with subfoveal neovascular membranes. Methods: A prospective, non-controlled surgical study in eight consecutive patients operated between February and July 2001 with final data monitoring in July 2002. All patients had mixed subfoveal membranes of 2–4 disc diameters. Functional tests included Snellen vision and central fixation testing. During vitrectomy, after the extraction of the neovascular complex, 8×104–16×104 RPE cells were removed from the periphery and translocated under the macula following the submacular injection of 2 μg of poly-l-lysine to promote adhesion of the cells. Results: With a follow up ranging from 3 months to 16 months, a pigmented area was seen in the extraction bed of the neovascular membrane in only one patient. Fixation was at the edge of the extraction bed in three patients. Vision remained the same in five patients and deteriorated in three (all with retinal detachment). Retinal detachment due to proliferative vitreoretinopathy occurred in three patients. Conclusions: The translocation of autologous peripheral RPE cells after membrane extraction was technically possible in a sterile manner, but was associated with a high proliferative vitreoretinopathy rate and in the present series had no measurable positive effect on functional outcome. |
| Databáze: | OpenAIRE |
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