| Popis: |
Promazine, a new phenothiazine derivative, appears to offer considerable promise in the control of patients with increased psychomotor activity1,2as well as assisting in the management of patients with various medical emergencies.3The exact physiological mechanism by which this drug exerts its effects is not known; however, previous studies4have shown chlorpromazine, a somewhat similar phenothiazine derivative, to have no demonstrable effects upon total cerebral hemodynamics and oxygen utilization. It was nevertheless considered worth while to determine whether this was also true of promazine. In addition, this study afforded the opportunity to examine the clinical and quantitative cerebral effects of methylphenidate hydrochloride (an analeptic drug) alone and upon subjects to whom promazine had been previously administered. Methods The subjects of the present study were 21 hospital patients who had been admitted for a variety of acute illnesses but were convalescent and otherwise in reasonably good condition. They |
