In Vitro Anticancer and Antivirus Activities of Cyano- and Bis(Trifluoromethylsulfonyl)imide-Based Ionic Liquids
| Autor: | Agnieszka B. Olejniczak, Marzena Dzida, Edward Zorębski, Marta Denel-Bobrowska, Małgorzata Musiał |
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| Rok vydání: | 2021 |
| Předmět: |
nontumor cells
Renewable Energy Sustainability and the Environment viruses General Chemical Engineering General Chemistry In vitro ionic liquids chemistry.chemical_compound anticancer activity chemistry Ionic liquid cancer cells antiviral activity cytotoxicity Environmental Chemistry Organic chemistry Imide |
| Zdroj: | ACS Sustainable Chemistry & Engineering. 9:16459-16465 |
| ISSN: | 2168-0485 |
| DOI: | 10.1021/acssuschemeng.1c06580 |
| Popis: | In the current work, we present a broad analysis of cytotoxicity toward normal (kidney and lung) and cancer (lung, liver, and cervix) cells of ionic liquids (ILs) with imidazolium cations and cyano-based or bis(trifluoromethylsulfonyl)imide anions. Additionally, we verify if ILs might be candidates for new potential virucidal agents. We observed the highest biological activity for 1-methyl-3- octylimidazolium bis(trifluoromethylsulfonyl)imide, whereas the least toxic was 1-ethyl-3-methylimidazolium thiocyanate. We found that all investigated ILs revealed a lack of antiviral activity against viruses: human parainfluenza virus type 3 (HPIV-3), human adenovirus 5 (AdV5), human herpesvirus 1 (HSV-1), and human herpesvirus 5 (HCMV) in nontoxic concentrations. |
| Databáze: | OpenAIRE |
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