Feasibility of shortened methacholine challenge in preschool children
| Autor: | R.A. Primhak, J. Kivastik, A.-M. Gibson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pediatrics medicine.medical_specialty Bronchoconstriction Bronchoconstrictor Agents Oxygen Consumption Wheeze Administration Inhalation medicine Humans Child Methacholine Chloride Oxygen saturation (medicine) Asthma Inhalation Dose-Response Relationship Drug business.industry Nebulizers and Vaporizers medicine.disease Methacholine challenge Nebulizer El Niño Child Preschool Pediatrics Perinatology and Child Health Feasibility Studies Methacholine medicine.symptom Bronchial Hyperreactivity business medicine.drug |
| Zdroj: | Pediatric pulmonology. 41(2) |
| ISSN: | 8755-6863 |
| Popis: | The aim of our study was to assess the feasibility and safety of a recently suggested tripling-dose methacholine (Mch) challenge in preschool children. Fifty-seven children aged 3-6 years were studied. Mch challenge was carried out using a tidal breathing method, with concentrations of 0.22, 0.66, 2.0, 6.0, and 18.0 mg/ml, at 5-min intervals, given by a Pari Turbo Boy compressor and Pari LC Plus nebulizer, for 1 min only. Oxygen saturation (SaO(2)) was monitored during the challenge. The challenge was terminated if there was wheeze, SaO(2) below 91%, or persistent cough. This final Mch dose was considered the provocative concentration inducing audible wheeze (PCW). Nine healthy children, 17 with cough and 25 with wheeze, completed the study. Mean output from nebulizers (SD) in these 51 children was 0.30 (0.05) ml/min. Geometric means for PCW in these groups were 2.88, 2.58, and 1.28 mg/ml Mch, respectively. The wheezing children were significantly more hyperresponsive than the coughing children (P < 0.05). A tripling-dose Mch protocol is safe and practicable in children over 3 years of age. A further reduction in nebulized dose may be needed for a more discriminatory test. |
| Databáze: | OpenAIRE |
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