Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists

Autor:	Chen Zhao, Robert J. Altenbach, Ramin Faghih, Arthur A. Hancock, Lawrence A. Black, Marlon D. Cowart
Rok vydání:	2004
Předmět:	Pharmacology Histamine Antagonists Imidazoles General Medicine Biology Structure-Activity Relationship chemistry.chemical_compound chemistry Biological property Drug Discovery Animal Disease Models Animals Humans Receptors Histamine H3 Histamine H3 receptor Histamine Benzofurans
Zdroj:	Mini-Reviews in Medicinal Chemistry. 4:979-992
ISSN:	1389-5575
DOI:	10.2174/1389557043403215
Popis:	The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760cea2b83863fca53bb3ec2f6a898a7 https://doi.org/10.2174/1389557043403215 Zobrazit plný text záznamu