Aspirin alleviates orthopedic implant‑associated infection
| Autor: | Hang‑Tian Wu, Bin Yu, Sheng‑Nan Wang, Han‑Jun Qin, Ming‑Liang Ren, Jian‑Chun Lin, Yi Jiang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Staphylococcus aureus medicine.medical_specialty Prosthesis-Related Infections Osteolysis Analgesic Periosteal reaction medicine.disease_cause Gastroenterology Mice 03 medical and health sciences fluids and secretions 0302 clinical medicine Internal medicine Genetics Animals Humans Medicine Antipyretic Tibia Aspirin business.industry Anti-Inflammatory Agents Non-Steroidal bacterial infection Prostheses and Implants X-Ray Microtomography Articles General Medicine Staphylococcal Infections medicine.disease Immunohistochemistry Molecular medicine female genital diseases and pregnancy complications Disease Models Animal 030104 developmental biology 030220 oncology & carcinogenesis embryonic structures Female business medicine.drug |
| Zdroj: | International Journal of Molecular Medicine |
| ISSN: | 1791-244X 1107-3756 |
| DOI: | 10.3892/ijmm.2019.4298 |
| Popis: | Implant-associated infection (IAI), a common condition marked by progressive inflammation and bone destruction, is mentally and financially devastating to those it affects, causing severe morbidity, prolonged hospital admissions, significant hospital costs and, in certain cases, mortality. Aspirin, a popular synthetic compound with a history of >100 years, is antipyretic, anti-inflammatory and analgesic. It is the most active component of non-steroidal anti-inflammatory drugs. However, the effects of aspirin on IAI remain unknown. In the present study, an IAI animal model was used, in which a stainless steel pin coated with Staphylococcus aureus was implanted through the left shaft of the tibia in mice. The animals were then randomized into five groups and subjected respectively to IAI, IAI + 15 mg aspirin treatment, IAI + 30 mg aspirin treatment, IAI + 60 mg aspirin treatment and IAI + 120 mg aspirin treatment groups. Aspirin was injected intraperitoneally twice daily for 11 days. Micro-CT and histological assays were performed to assess the effects of aspirin on IAI. It was found that aspirin reduced osteolysis and periosteal reaction, inhibited the activation of osteoclasts, promoted the activation of osteoblasts and facilitated healing of the infected fracture. |
| Databáze: | OpenAIRE |
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