Identification of Pasteurella multocida CHAPS-Soluble Outer Membrane Proteins
| Autor: | Louisa B. Tabatabai |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Lactate permease
Pasteurella multocida Attenuated vaccine General Immunology and Microbiology biology Protein subunit Detergents Virulence Cholic Acids Building and Construction biology.organism_classification Peptide Mapping Virology Microbiology Solubility Food Animals Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Proteome Animal Science and Zoology Fowl cholera Bacterial outer membrane Bacterial Outer Membrane Proteins |
| Zdroj: | Avian Diseases. 52:147-149 |
| ISSN: | 1938-4351 0005-2086 1560-3857 |
| Popis: | Fowl cholera continues to be of concern to the poultry industry, especially for turkey growers. This disease costs the turkey industry millions of dollars annually. In order to develop improved live attenuated vaccines or subunit vaccines, the outer-membrane proteins of Pasteurella multocida were examined with the use of proteomics. Of the 11 proteins total present in an outer-membrane subfraction of P. multocida, four additional proteins were identified, completing the composition of the detergent-soluble cross-protective protein fraction. These additional four proteins include protective bacterial surface antigen, OMA87 (Accession no. 15603857); heme–hemopexin receptor, HemR (Accession no. 15602441); lactate permease, LctP (Accession no. 15603717); and heptosyl transferase F, RfaF (Accession no. 15603709). Both the Oma87 and the HemR proteins would be of interest for subunit and modified live vaccine studies, respectively, because of their purported roles as virulence factors for P. multocida. |
| Databáze: | OpenAIRE |
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