Lack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population
| Autor: | Guiju Wang, Chuanping Gao, Shiguo Liu, Wenmiao Liu, Shiyan Qiu, Hongzai Guan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Candidate gene Linkage disequilibrium Adolescent Genotype Single-nucleotide polymorphism Biology Tourette syndrome Polymorphism Single Nucleotide Linkage Disequilibrium 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency medicine SNP Humans Genetic Predisposition to Disease Child Allele frequency Genetics Symporters General Neuroscience Haplotype Transmission disequilibrium test medicine.disease 030104 developmental biology Child Preschool Female 030217 neurology & neurosurgery Tourette Syndrome |
| Zdroj: | Neuroscience letters. 658 |
| ISSN: | 1872-7972 |
| Popis: | Although Tourette syndrome (TS) is a chronic neuropsychiatric disorder whose pathogenesis remains unclear, genetic factors play an important role in the occurrence and development. A variety of studies have been shown that the candidate genes related to cholinergic neurons may be associated with the onset of TS. To investigate the association between the SLC5A7 polymorphisms and Tourette syndrome (TS) in the Chinese Han population, the SNP rs1013940, rs2433718, and rs4676169 were genotyped in 401 TS trios and 400 controls. The transmission disequilibrium test (TDT) and haplotype relative risk (HRR) compared genetic distributions of trios, while the chi-square test compared patients and controls. However, no transmission disequilibrium was found between the three SLC5A7 SNPs and TS. Therefore, we think that this gene may not be the main risk factor on the onset of TS. However, these results should be further validated in different populations. |
| Databáze: | OpenAIRE |
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