Clinical Impact of Neoadjuvant Chemotherapy and Chemoradiotherapy in Borderline Resectable Pancreatic Cancer: Analysis of 884 Patients at Facilities Specializing in Pancreatic Surgery
| Autor: | Tsutomu Fujii, Hiroki Yamaue, Yatsuka Sahara, Yoshiaki Murakami, Sohei Satoi, Tetsuo Ohta, Shigeyuki Kawachi, Yosuke Hijikata, Shuji Isaji, Shuji Suzuki, Masayuki Sho, Yuichi Hosokawa, Kenji Katsumata, Itaru Endo, Yuichi Nagakawa, Akihiko Tsuchida, Michiaki Unno, Chie Takishita, Takukazu Nagakawa |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment 030230 surgery Gastroenterology Specialties Surgical 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine Pancreatic cancer Antineoplastic Combined Chemotherapy Protocols medicine Humans Lymph node Survival rate Neoadjuvant therapy Aged Retrospective Studies Aged 80 and over Chemotherapy business.industry Retrospective cohort study Chemoradiotherapy Middle Aged Prognosis medicine.disease Combined Modality Therapy Neoadjuvant Therapy Pancreatic Neoplasms Survival Rate medicine.anatomical_structure Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Female Surgery business Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology. 26:1629-1636 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-018-07131-8 |
| Popis: | The efficacy of neoadjuvant therapy (NAT), including neoadjuvant chemotherapy (NAC) and neoadjuvant chemo-radiotherapy (NACRT), for patients with borderline resectable pancreatic cancer (BRPC) has not been elucidated. This study aimed to clarify the efficacy of NAC and NACRT for patients with BRPC. The study analyzed the treatment outcomes of 884 patients treated for BRPC from 2011 to 2013. Treatment results were compared between upfront surgery and NAT and between NAC and NACRT using propensity score-matching analysis. Overall survival (OS) was calculated via intention-to-treat analyses. The overall resection rates for the patients who underwent NAT were significantly lower than for the patients who underwent upfront surgery (75.1% vs 93.3%; p |
| Databáze: | OpenAIRE |
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